Sodium cefetaxime and sodium tazotactam compound preparation for injection

A technology of cefotaxime sodium and tazobactam sodium, which is applied in the direction of antibacterial drugs, can solve the problems of serious drug resistance, achieve the effects of increasing adverse reactions, major social and economic benefits, and enhancing clinical antibacterial effects

Inactive Publication Date: 2003-06-25
海南国瑞堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] β-lactam antibiotics are the most clinically used and most important class of antibiotics. The advantages of these drugs are broad-spectrum antibacterial and less toxic and side effects. However, due to the long history of clinical application of these drugs, some varieties Drug resistance is also more serious

Method used

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Examples

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Embodiment Construction

[0012] specific implementation plan

[0013] The content of the present invention is specifically described below in conjunction with the examples.

[0014] The compound preparation is composed of cefotaxime sodium and tazobactam sodium in a ratio of 5:1 (weight ratio). First prepare tazobactam sodium, make mixed suspension by 200g of tazobactam sodium and water for injection, add sodium bicarbonate solution to adjust the pH value to 6.3 ± 0.1 to obtain tazobactam sodium solution, decolorize through activated carbon for injection, Sterilization, filtration, freeze-drying to obtain freeze-dried tazobactam sodium powder, crushed to obtain tazobactam sodium powder; then mix 1000g of cefotaxime sodium with tazobactam sodium evenly, and pack in 1000 bottles to obtain the final product Cefotaxime sodium and tazobactam sodium form a compound preparation in a ratio of 5:1 (by weight).

[0015] In vivo antibacterial test showed that the 5:1 ratio of cefotaxime sodium and tazobactam s...

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PUM

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Abstract

The present invention relates to sodium cefetaxima and sodium tazobactam compound injection preparation. It features that the compound injection preparation consists of sodium cefetaxima and sodium tazobactam in the weight ratio of 5. It has synergetic and accumulated antibacterial effect to drug resisting bacteria strains, strengthened clinical antibacterial effect and no increased negative effect.

Description

technical field [0001] The invention relates to a compound preparation composed of cefotaxime sodium and tazobactam sodium. Background technique [0002] Various microbial infections are one of the main factors causing human diseases. Since humans invented antibacterial drugs, humans have overcome many diseases caused by bacteria. Over the past few decades, humans have invented a large number of antibacterial drugs, and at present there are no less than 200 kinds of them in clinical application, and they are still increasing at an average rate of more than 10 new antibacterial drugs coming out every year. With the widespread use of antibacterial drugs, the emergence of bacterial resistance has become a difficult problem in clinical treatment. Bacteria retain their most drug-resistant strains under wide-ranging selective pressure, and this drug resistance can spread among bacteria, and drug-resistant bacteria can spread around the world, so the infection of multi-drug resist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04
Inventor 阎彬
Owner 海南国瑞堂制药有限公司
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