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Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases

A technology of extract and hibiscus, applied in the field of anti-cerebrovascular disease and atherosclerosis drug preparation of hibiscus extract, can solve the problem of easy oxidation of LDL

Inactive Publication Date: 2003-06-04
AIKEN BIOTECH INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, plasma LDL contains too little antioxidants, too high a proportion of polyunsaturated fatty acids (PUFAs) or too high a concentration of Cu in plasma ++ , Fe ++ And other factors, will lead to easy oxidation of LDL, and it is the most important positive risk factor for atherosclerosis

Method used

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  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases
  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases
  • Application of Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases

Examples

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example 1

[0022] The following compounding examples illustrate the present invention in detail. This is to specifically illustrate the present invention, but not to limit the present invention. Example 1: Inhibitory effect on LDL oxidation

[0023] When LDL is not oxidized, its molecular weight is small, so it moves faster in gel electrophoresis experiments at the same potential. When LDL is oxidized, its molecular weight is larger, and relatively slower in gel electrophoresis experiments at the same potential. We added different concentrations of roselle extract (0.5, 1, 2mg / ml) and 10μM copper sulfate (CuSO 4 ) and 100mM sodium nitroprusside (Sodium Nitroprusside (SNP)) together at 37 degrees Celsius to induce LDL oxidation for 24 hours, it can be found that the higher the concentration of the roselle extract, the more significant the effect of inhibiting LDL oxidation, The faster the electrophoretic movement rate. Adding Roselle extract to inhibit LDL oxidation after SNP-induced L...

example 2

[0044] From the above experiments, it can be known that the addition of roselle extract can effectively inhibit the oxidation of LDL no matter before, after or at the same time when LDL is induced to oxidize, and the higher the concentration of roselle extract, the better the effect of inhibiting LDL oxidation. Example 2: Lowering Triglyceride and Cholesterol in Experimental Animals

[0045] The experimental animals used in the present invention are New Zealand white rabbits (about 2-2.2 kilograms in body weight) and Sprague-Dawley rats (about 200-220 grams in body weight). A total of 30 rabbits were divided into 5 groups, 1 in each cage, 150g diet per day, among which 3 groups were fed with 95.7% solid food, 3% lard and 1.3% cholesterol for 10 weeks, which could induce atherosclerosis, The roselle extract test group then added 1% or 0.5% roselle extract; a total of 24 rats were divided into 4 groups, 6 in each cage, and 25g diet per day, of which three groups were fed with 95...

example 3

[0047] The rats were divided into 4 groups, 6 in each group, the first group was fed with normal diet, the second group was fed with high cholesterol diet (containing 1.3% cholesterol and 3% lard), the third group was fed with 1% roselle extract High-cholesterol diet, the fourth group was fed a high-cholesterol diet supplemented with 2% roselle extract; after 12 weeks, the head was decapitated and bled, the blood was collected into EDTA-coated test tubes, and then centrifuged to analyze the content of cholesterol in plasma, the results showed , high-cholesterol diet can increase blood cholesterol in rats by 1.6 times, LDL-C by 3 times, and LDL-C / HDL-C / by 2.6 times; adding 1% of Roselle extract can increase the levels of cholesterol and LDL-C in plasma The content decreased significantly (p Figure 6 shown. It is more confirmed that the extract of roselle flower can lower the cholesterol in plasma. Example 3: Inhibition of atherosclerosis

[0048] The deposition of endothelia...

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Abstract

It is found that Hibiscus sabdariffa Linn extractive has the functions of reducing triglyceride and cholesterin in blood, inhibiting the oxidation of low-density lipoprotein, decreasing the fat deposition on arterial endodermis, improving the smooth muscle migration caused by spumescent cell formed on the blood vessel wall, etc. The present invention provides the application of the Hibiscus sabdariffa Linn extractive in preparing medicine for inhibiting cardiac and cerebral vascular diseases.

Description

technical field [0001] The present invention relates to a new application of the extract of the roselle flower, more specifically, it relates to the use of the extract of the roselle flower for preparing drugs for inhibiting cerebrovascular diseases and atherosclerosis. Background technique [0002] In the past, hibiscus tea was used by folks for antipyretic, antihypertensive and treatment of liver diseases. However, no one really understands that the roselle extract has the function of inhibiting cerebrovascular diseases and atherosclerosis, and the present invention lies in the discovery of this new use. [0003] According to research, in recent years, cerebrovascular disease and heart disease have ranked among the top causes of death. Although both cerebrovascular disease and heart disease are caused by the interaction of multiple factors, according to many research data, atherosclerosis is the leading cause of death. The leading cause of these va...

Claims

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Application Information

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IPC IPC(8): A61P3/06A61P9/10
Inventor 王朝钟
Owner AIKEN BIOTECH INT
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