Synthesis of 1,3-terahydro thiazolone compound

Abstract

The present invention relates to the synthesis of 1,3-tetrahydro thiazolone-2 compounds as important intermediate for farm pesticide and some medicines. Compound 1,3-tetrahydro thiazothione-2 and epoxy ethane as materials are reacted. The solvent used in the reaction is at least one of water, C1-C4 fatty alcohol, C1-C4 fatty ketone, C1-C4 fatty ester, benzene, toluene, tetrahydrofuran, acetonitrile, dimethylformamide and dimethyl sulfoxide. The present invention has simple reaction condition, high product purity and high industrial application value. Through selecting and regulating solvent, epithioethane or polyglycol sulfide product may be obtained at the same time.

Description

technical field [0001] The invention relates to a synthetic method for preparing 1,3-tetrahydrothiazolone-2 compounds as important intermediates of pesticides and certain medicines. Background technique [0002] 1,3-Tetrahydrothiazolone-2 compounds (I) are important intermediates of some pesticides and medicines. With the difference of the initial raw materials used in the synthesis, the synthetic methods reported so far can include: [0003] The above synthetic methods have their own characteristics and problems respectively. For example, some require strict labor protection facilities because of the use of toxic gases such as phosgene; some use expensive raw materials such as aminoethanol, which makes the cost of the obtained target compound too high and difficult to achieve commercialization Production; some have too high requirements for reaction conditions, so that large-scale industrial production is limited; some have too many impurities in the synthetic product a...

AI Technical Summary

Problems solved by technology

However, because the dioxane used in the reaction is expensive, the reaction process needs to be operated under pressure, and ether must be used in the process.

All of these have made it difficult to apply in large-scale industrial production.