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Process for preparing slow-releasing indapamide tablet

A technology for indapamide and its manufacturing method, which is applied in the field of manufacturing indapamide sustained-release tablets, can solve problems such as high cost, complex production process, and unsuitability for popularization and application, and achieve low cost, low investment, and easy control Effect

Inactive Publication Date: 2003-02-19
TIANJIN HANRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the production process of sodium urging indapamide sustained-release tablets produced by Servier Company in France is very complicated and costly, so it is not suitable for a large number of popularization and application in China; and no new process for producing this sustained-release tablets has been found in China at present. Seen in the report

Method used

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  • Process for preparing slow-releasing indapamide tablet
  • Process for preparing slow-releasing indapamide tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Based on 1000 indapamide sustained-release tablets, take 1.5 g of indapamide that was pulverized and screened through a 200-mesh sieve, and weigh 100 g of hydroxypropyl methylcellulose, 30 g of Crystalline cellulose, 10g sodium carboxymethyl starch and 60g sucrose, put these raw materials in a mixer and mix evenly, and make soft material with water, then use 30-mesh nylon mesh to make granules with less fine powder and neat without long strips . Dry the granules at a temperature of 60±2°C. After drying, sieve and size the granules to remove oversized particles, then add 10g of magnesium stearate screened through a 100-mesh sieve and mix evenly. Tablets were made into 1000 core tablets containing 1.5 mg of indapamide. At the same time, weigh 3g of methyl cellulose, add 70ml of distilled water under stirring conditions, and use ultrasonic treatment, then add 70ml of distilled water until the solution is clear, then add 15g of talcum powder and 8g of titanium dioxide and ...

Embodiment 2

[0012] Based on 1000 indapamide sustained-release tablets, 1.5g indapamide, 10g methylcellulose, 30g hydroxypropylcellulose, 5g lactose, 15g mannitol, 40g modified starch and 1g magnesium stearate Add-on and the same process of embodiment 1 are made into tablet cores. Simultaneously according to 20g hydroxyethyl cellulose, 8g talcum powder, 1g titanium dioxide, 5ml macrogol 400, 140ml distilled water and the ethanol add-on that adds to 500ml coating solution at last and make coating solution with the technique identical with embodiment 1 . The method of coating treatment is also the same as in Example 1.

Embodiment 3

[0014] Based on 1000 indapamide sustained-release tablets, according to the addition amount and embodiment of 1.5g indapamide, 60g methylcellulose, 30g sodium alginate, 70g lactose, 30g modified starch and 8g magnesium stearate 1 The core is made by the same process. Simultaneously according to 8g hydroxypropyl cellulose, 2g talcum powder, 15g titanium dioxide, 5ml macrogol 400, 140ml distilled water and the ethanol add-on that is finally added to 500ml coating solution and the process identical with embodiment 1 makes coating solution . The method of coating treatment is also the same as in Example 1.

[0015] A low-dose antihypertensive sustained-release drug containing 1.5 mg of indapamide active ingredient can be produced by using the manufacturing method of the indapamide sustained-release tablet provided by the present invention, and the patient only needs to take one tablet per day to reach the therapeutic concentration. Compared with low-dose indapamide sustained-rel...

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Abstract

An antihypertensive slow-releasing indapamide tablet is prepared through mixing indapamide with slow-releasing material, pore-forming agent and filler, adding water, granulating, mixing with lubricant, tabletting to obtain tablet cores, preparing solution A fron distilled water, filming agent, antisticking agent and masking agent, preparing solution B from alcohol and polyethanediol 400, mixing A with B, diluting, coating on tablet cores, and drying.

Description

technical field [0001] The present invention relates to a kind of manufacturing method of medicine, particularly relate to a kind of manufacturing method of the indapamide sustained-release tablet that can treat hypertension and edema. Background technique [0002] Hypertension is a common and frequently-occurring disease with a high morbidity rate. If it is not treated properly or not treated in time, it may lead to serious complications and endanger the patient's physical and mental health, and even life-threatening. Indapamide is a first-line antihypertensive drug, which is clinically used to treat various hypertension and edema. It has the advantages of safety, effectiveness, convenience, rapid oral absorption, safety and reliable efficacy. At present, the production process of sodium urging indapamide sustained-release tablets produced by Servier Company in France is very complicated and costly, so it is not suitable for a large number of popularization and application ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/24A61K9/28A61K31/404A61P9/12
Inventor 严洁
Owner TIANJIN HANRUI PHARMA
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