Methods and compositions for reducing sympathomimetic-induced side effects
A technology of sympathomimetic drugs and compositions, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.
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Embodiment 1
[0060] Embodiment 1: Activity experiment
[0061] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.
[0062] In a specific embodiment, a rat model of seminal vesicle contractility is utilized, wherein the activity of seminal vesicle muscles can be altered pharmacologically by alpha-adrenergic agents. See "An In Vivo Microsurgical Animal Model of Seminal Vesicle Contractility: Role of Alpha-Adrenergic Agents," American Society for Reproductive Medicine, 1996 Annual Meeting, P.J. Turek, A.K. Younes, K. Aslam. Department of Urology, University of California, San Francisco, CA.
[0063] An in vivo rat model of seminal vesicle contractility was studied using hypogastric nerve stimulation. In vivo seminal vesicle contractili...
Embodiment 2
[0066] Embodiment 2: Activity experiment
[0067] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.
[0068] α-Adrenergic receptor-mediated constriction of isolated rat thoracic arteries was assayed as described by Hamed et al. "Alpha-adrenergic receptor subtypes in isolated rat thoracic arteries Pharmacological Properties," J Auton Pharmacol 3(4):265-73, 1983. α-Adrenergic receptor-mediated effects of isolated large Constriction of the rat thoracic artery was measured.
Embodiment 3
[0069] Embodiment 3: Activity experiment
[0070] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.
[0071] Administration of saw palmetto or an extract thereof, as an alpha-adrenergic receptor blocker, to patients prior to or concurrently with sympathomimetic agents. Blood pressure and heart rate are measured serially before and after dosing, eg, using established invasive techniques, over extended, unfixed periods. The experimental protocol was randomized, double-blind and double-sham placebo-controlled. A standard procedure test of physiological stress was also administered in each study. During a 24-hour period, changes in blood pressure levels and patterns, and physiological tests for side effects such as hypoten...
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