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Methods and compositions for reducing sympathomimetic-induced side effects

A technology of sympathomimetic drugs and compositions, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2002-10-23
IMAGINUTRITION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Seven of the eight reported fatalities were due to myocardial infarction or cerebrovascular accidents, and although the reports lacked sufficient information on a definitive cause, they suggested potential health risks that may accompany the use of ephedrine-containing products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: Activity experiment

[0061] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.

[0062] In a specific embodiment, a rat model of seminal vesicle contractility is utilized, wherein the activity of seminal vesicle muscles can be altered pharmacologically by alpha-adrenergic agents. See "An In Vivo Microsurgical Animal Model of Seminal Vesicle Contractility: Role of Alpha-Adrenergic Agents," American Society for Reproductive Medicine, 1996 Annual Meeting, P.J. Turek, A.K. Younes, K. Aslam. Department of Urology, University of California, San Francisco, CA.

[0063] An in vivo rat model of seminal vesicle contractility was studied using hypogastric nerve stimulation. In vivo seminal vesicle contractili...

Embodiment 2

[0066] Embodiment 2: Activity experiment

[0067] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.

[0068] α-Adrenergic receptor-mediated constriction of isolated rat thoracic arteries was assayed as described by Hamed et al. "Alpha-adrenergic receptor subtypes in isolated rat thoracic arteries Pharmacological Properties," J Auton Pharmacol 3(4):265-73, 1983. α-Adrenergic receptor-mediated effects of isolated large Constriction of the rat thoracic artery was measured.

Embodiment 3

[0069] Embodiment 3: Activity experiment

[0070] The effective concentrations of saw palmetto or its extracts to reduce the side effects of sympathomimetic drugs were tested using validated professional methods. In a specific embodiment, the amount of saw palmetto or an extract thereof used is an effective amount as an alpha-adrenergic receptor antagonist.

[0071] Administration of saw palmetto or an extract thereof, as an alpha-adrenergic receptor blocker, to patients prior to or concurrently with sympathomimetic agents. Blood pressure and heart rate are measured serially before and after dosing, eg, using established invasive techniques, over extended, unfixed periods. The experimental protocol was randomized, double-blind and double-sham placebo-controlled. A standard procedure test of physiological stress was also administered in each study. During a 24-hour period, changes in blood pressure levels and patterns, and physiological tests for side effects such as hypoten...

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PUM

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Abstract

The present invention provides compositions comprising saw palmetto and extracts thereof and sympathomimetic agents which are useful in the management of various physiological conditions including obesity, appetite suppression, decongestion, asthma and energy stimulation. Side effects are reduced when saw palmetto or its extracts are added to pharmaceutical dosage forms with sympathomimetic activity, or when they are administered in combination with sympathomimetic agents. Thus, the debilitating side effects associated with the use of agents that stimulate adrenergic receptors and exhibit sympathomimetic effects can be reduced.

Description

technical field [0001] The present invention relates to compositions containing Serenoa repens for use in pharmaceutical, cosmetic, food and food supplement formulations. The present invention relates to compositions comprising Serenoa repens and agents having undesired sympathomimetic activity and their clinical and veterinary uses. [0002] The present invention is concerned with reducing the debilitating, locomotion and undesirable side effects associated with the use of agents which activate adrenergic receptors or exhibit sympathomimetic activity. Background technique [0003] Throughout this application, various publications, patents, and published patent applications are referenced by specific citations; full citations to these documents can be found at the end of the specification. The publications, patents, and published patent applications mentioned herein are hereby incorporated by reference in their entirety. [0004] Sympathomimetics are w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135A61K36/889A61P3/00A61P5/38A61P11/00
CPCA61K36/752A61K36/889A61P3/00A61P5/38A61P11/00A61K2300/00
Inventor A·L·阿尔玛德
Owner IMAGINUTRITION
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