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Process for extracting, separating and refining amygdalin

A technology for amygdalin and active ingredients, which is applied in the field of separation and purification, and extraction of the active ingredient amygdalin, can solve the problems of difficult to detect amygdalin, difficult to qualitatively detect, difficult to measure the content, etc., and to promote the modernization of traditional Chinese medicine. , reduce damage, ensure the effect of curative effect

Inactive Publication Date: 2002-08-28
药都制药集团股份有限公司
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Problems solved by technology

[0003] However, it is often difficult to detect amygdalin in the preparations added with the original medicinal materials of bitter almonds due to enzymatic hydrolysis.
In the preparations for extraction and processing, the current extraction process of amygdalin is mostly boiling the total extract or steam distillation. Since amygdalin is heated in water for a long time, it is easily destroyed, and its content is relatively low. , difficult to determine the content, even difficult to detect qualitatively

Method used

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  • Process for extracting, separating and refining amygdalin
  • Process for extracting, separating and refining amygdalin
  • Process for extracting, separating and refining amygdalin

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Embodiment 1

[0018] Take 1.5 kg of bitter almond cake after pressing to remove oil, coarsely crush it, add 4.5-9 kg of ethanol, reflux extraction 3 times, suction filter while it is hot, combine the filtrate, recover ethanol to an appropriate amount under reduced pressure, refrigerate, place, and precipitate amygdalin. Suction filtration and drying yielded 120 g of crude amygdalin, with a yield of 8%. The content of amygdalin in the crude amygdalin was determined to be 60%.

[0019] Then take 5g of the crude product of amygdalin, add ethanol to dissolve, filter, refrigerate, and precipitate white cluster crystals of bitter almonds, filter under reduced pressure, wash the crystals with a small amount of ether and ethanol, repeat the above operation 1 to 2 times, and obtain amygdalin Quantitative reference substance 1.5 ~ 2.5g. The melting point is 214.8-216.5°C, and its purity is 99.2% measured by high-performance liquid phase normalization method.

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Abstract

A process for extracting, separating and refining amygdalin includes such steps as squeezing bitter apricot kernels to remove oil, then extracting in alcohol three times, pressure reduction filtering, merging the filtrate, pressure reduction recovery of alcohol, laying aside to educe out white cluster crystal of amygdalin, filtering to obtain the coarse product, dissolving in alcohol, filtering, cold storage, educing out amygdalin crystal, pressure reduction filtering, and washing crystal with ether or alcohol to obtain the pure product. Its adgantages are high purity (more than 99%), and high extraction rate.

Description

technical field [0001] The invention relates to a method for extracting, separating and refining the active ingredient amygdalin. Background technique [0002] Bitter almond is a variety collected in the Chinese Pharmacopoeia. It has the effects of reducing qi, relieving cough, relieving asthma, and laxative. medicine. According to literature reports, the effective cough-relieving ingredient of bitter almond is mainly amygdalin, which is slowly decomposed in the body, gradually producing traces of hydrocyanic acid, which inhibits the respiratory center, quiets the breathing movement, and presents an antitussive and asthma-relieving effect. In addition, bitter almonds and their decomposition products also have a sedative effect. [0003] However, it is often difficult to detect amygdalin in preparations added with bitter almond raw medicinal materials due to enzymatic hydrolysis. In the preparations for extraction and processing, the current extraction process of amygdalin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H15/18
Inventor 韩桂茹赵志军徐韧柳
Owner 药都制药集团股份有限公司
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