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Loselofen sodium injection and its prepn

A technology of loxoprofen sodium and dosage form, applied in the field of injection dosage form of loxoprofen sodium and its preparation, achieving remarkable effect, quick effect and low toxicity

Inactive Publication Date: 2002-07-10
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Loxoprofen sodium has not been made into injections for injection route administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Present embodiment prescription is as follows:

[0015] Consumption per 1 stick Consumption per 1000 sticks

[0016] Loxoprofen sodium (according to anhydrous substance) 60mg 60g

[0017] Mannitol 20mg 20g

[0018] Add water for injection to 5ml 5L

[0019] Dissolve the main drug loxoprofen sodium (105% feeding intake according to the prescription quantity) in water, add sodium chloride to dissolve, add water to volume, mix well, heat and keep warm at 60~70°C; add 0.1% activated carbon for needles, 60 ~70°C heat preservation for about 20 minutes, sand core filter decarburization; filling; nitrogen filling, sealing; 115°C autoclaving for 30 minutes; quality inspection, that is, 5ml of cloxoprofen sodium injection.

Embodiment 2

[0021] Present embodiment prescription is as follows:

[0022] Dosage per 1 bottle Dosage per 1000 bottles

[0023] Loxoprofen sodium (according to anhydrous substance) 60mg 60g

[0024] Sodium chloride 900mg 900g

[0025] Add water for injection to 100ml 100L

[0026] Dissolve the main drug loxoprofen sodium (105% feeding intake according to the prescription amount) in water, add sodium chloride to dissolve, add water to volume, mix well, heat and keep warm at 60-70°C; add 0.1% activated carbon for needles, 60 ~70°C heat preservation for about 30 minutes, sand core filtration decarbonization; filling; nitrogen filling, sealing; 115°C autoclaving for 30 minutes; quality inspection, that is, 100ml of loxoprofen sodium infusion.

Embodiment 3

[0028] Present embodiment prescription is as follows:

[0029] Dosage per 1 bottle Dosage per 1000 bottles

[0030] Loxoprofen sodium (according to anhydrous substance) 60mg 60g

[0031] Sorbitol 100mg 100g

[0032] Add water for injection to 2ml 2L

[0033] Dissolve the main drug loxoprofen sodium (105% of the prescription quantity) in water, add sorbitol to dissolve, add water to volume, mix well, heat and keep warm at 60-70°C; add 0.1% activated carbon for needles, Incubate at 70°C for about 20 minutes, decarbonize by sand core filtration; sterilize and filter with filter membrane, fill; freeze-dry in a freeze dryer; check quality to obtain loxoprofen sodium powder injection.

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PUM

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Abstract

The present invention provides loselofen sodium injection and its preparation. Available loselofen sodium dosage forms include oral tablet, capsule and granule only. The Rosorolfine sodium injection of the present invention is used for relieving pain and diminishing inflammation of chronic rheumatic arthritis, rheumatoid arthritis, lumbago, etc. and especially relieving serious pain of postoperation, fracture, strain, etc. It has obvious effects and no addiction. It is prepared by dissolving Rosorolfine sodium in water, adding proper amount of medicinal supplementary material, eliminating pyretogen, disinfection or filtering and may be prepared into water injection, transfusion agent to freezed dried powder for injection.

Description

technical field [0001] The invention relates to an injectable dosage form of loxoprofen sodium and a preparation method thereof. Background technique [0002] Loxoprofen sodium is a phenylpropionic acid non-steroidal anti-inflammatory drug, which was first synthesized and developed by Japan Sankyo Co., Ltd. and approved for marketing in 1986. It has good analgesic and anti-inflammatory effects, and is characterized by strong analgesic effect, anti-inflammatory and antipyretic effects similar to other similar drugs. At present, the drug has good analgesic and anti-inflammatory effects on chronic rheumatoid arthritis, osteoarthritis, lumbago, periarthritis of shoulder, neck and shoulder inflammation, postoperative and trauma. But since the drug's history, only tablets, capsules and granules have been given orally. Loxoprofen sodium has not been made into injections for administration by injection route. Contents of the invention [0003] The purpose of the invention is to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P29/00
Inventor 印春华
Owner FUDAN UNIV
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