Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy
A technology of bicarbonate and sodium bicarbonate is applied in peritoneal dialysis, devices that make medicines into special physical or oral forms, dialysis systems, etc. and other issues, to achieve the effect of low cost
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Embodiment 1
[0083] Example 1. Preparation of a bicarbonate-based concentrate with a pH of 8.6. Further pH adjustments can be made during storage. However, an initial adjustment ensures that the pH is within the physiological range (6.5-7.6) after mixing.
[0084] The container is a two-compartment bag with each compartment separated by a sealing skin. The pH of the bicarbonate-containing solution and the dextrose-containing solution should be matched to ensure that after mixing (1:1 volume ratio mixing) the pH is within the physiological range. The compositions and pH adjustments of the sterile dextrose and bicarbonate concentrates are listed in Tables 8 and 9, respectively.
[0085] composition
Glucose.H 2 O g / l
85.00
CaCl 2 .2H 2 O g / l
0.368
MgCl 2 .6H 2 O g / l
0.102
pH at ambient conditions
2.0 *
[0086] composition
10.76
3.36
4.20
8.6
Sodi...
Embodiment 2
[0092] Example 2. The pH of the bicarbonate concentrate was adjusted to about 9.5 by adding sodium hydroxide. After mixing with acidified glucose solution, the pH of the resulting mixture remained in the physiological range throughout the 6-month study.
[0093] The container is a two-compartment bag with the compartments separated by a seal. The pH of the bicarbonate-containing solution and the dextrose-containing solution should be matched to ensure that the pH is within the physiological range after mixing (1:1 volume ratio). The compositions and pH adjustments of the tested sterile dextrose and bicarbonate concentrates are listed in Tables 11 and 12, respectively.
[0094] composition
[0095] composition
[0096] * : Adjust the pH of the solution with NaOH
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