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Oral liquor composition with reduced bitter taste

A technology for oral preparations and compositions, which is applied in the field of oral preparations and compositions of sodium promethadienyl, and can solve problems such as difficulty in fully reducing bitterness

Inactive Publication Date: 2005-10-12
KOTOBUKI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the case of sodium prothylenediene, it is difficult to sufficiently reduce its bitterness only by using such a method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] By wet granulation method, 30g of sodium propylene adiene, 40g of crystalline cellulose, 1070g of cornstarch, 40g of aminoalkyl methacrylate copolymer E, and 20g of hydroxypropyl cellulose were granulated to form granules.

Embodiment 2

[0018] Mix 30 g of sodium proteadiene, 40 g of crystalline cellulose, 160 g of L-glutamine, and 970 g of cornstarch to make a powder.

Embodiment 3

[0020] Spray 20 g of methyl cellulose aqueous solution in the mixture of 30 g of sodium proteadiene, 60 g of crystalline cellulose, 24 g of L-sodium glutamate, and 1066 g of cornstarch, and granulate with fluidized bed granulation to make granules.

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PUM

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Abstract

The present invention relates to a bitterness-abated oral preparation composition formed by adding aminoalkyl methyl acrylate copolymer and / or glutamic acid compound in egg propadiene sodium. Said aminoalkyl methyl acrylate copolymer, optimum, is aminoalkyl methyl acrylate copolymer E and / or aminoalkyl methyl acrylate copolymer RS, and the glutamic acid compound optimally uses at least one of L-glutamine, L-sodium glutamate and L-potassium glutamate. It can greatly abate bitterness, and can be obtain egg propadient sodium oral preparation composition with good taking sense.

Description

technical field [0001] The invention relates to an oral preparation composition containing egg allenesodium (egg allenesodium) which is formulated with a bitterness-relieving agent. Background technique [0002] Ethyl allene sodium [chemical name: 3-ethyl-7-isopropyl-1-azulene sulfonate sodium 1 / 3 hydrate], after oral administration, has an excellent role in protecting the gastric mucosa, and is used as a treatment for gastric ulcers, etc. It is an excellent medicine for medicine, and it is also a medicine with a bitter taste. In the masking of the taste of pharmaceutical preparations containing such peculiar-tasting drugs, film coating is very effective for tablets, but for granules, fine granules, and powders, due to their large surface area, in order to use film coating Coating completely masks the bitter taste and requires a very thick film coating, so the disadvantage is that the dissolution in the digestive tract is very poor. [0003] As a method of reducing bittern...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/255A61K47/32
Inventor 富山刚富山格富山泰洼田光一
Owner KOTOBUKI PHARMA CO LTD
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