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Pharmaceutical composition

A composition and drug technology, applied in the direction of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve problems such as incompatibility of preparations

Inactive Publication Date: 2004-11-03
LEO PHARMA PROD LTD AS LOVENS CHEM FAB PRODUKTIONS AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This has the potential to lead to formulation incompatibility in the patient as the patient has to use another cream / ointment in the evening after using one cream / ointment in the morning
Needless to say, patient compliance and appropriate dosing becomes an issue in this case

Method used

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Examples

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example

[0011] Examples include:

[0012] alphacalcidol;

[0013] 1α-hydroxy-vitamin D2;

[0014] 1α-hydroxy-vitamin D5;

[0015] 1(S), 3(R)-Dihydroxy-20(R)-(5-Ethyl-5-hydroxy-1-heptyl)-9,10-Danpregna-5(Z), 7(E ), 10(19)-triene;

[0016] 1(S), 3(R)-Dihydroxy-20(R)-(6-Hydroxy-6-methyl-1-heptyl)-9,10-Danpregna-5(2), 7(E )10(19)-triene;

[0017] 1(S), 3(R)-Dihydroxy-20(R)-(6-Hydroxy-6-methylhept-1(E)-en-1-yl-9,10)-Danpregna-5 (Z), 7(E), 10(19)-triene;

[0018] 1(S), 3(R)-dihydroxy-20(R)-(6-ethyl-6-hydroxyl-1-octyl)-9, 10)-pregna-5(Z), 7( E), 10(19)-triene;

[0019] 1(S), 3(R)-dihydroxy-20(R)-(7-hydroxy-7-methyl-1-octyl)-9, 10)-dihydroxy-5(2), 7( E), 10(19)-triene;

[0020] 1(S), 3(R)-Dihydroxy-20(R)-(7-Hydroxy-7-methyloct-1(E)-en-1-yl-9,10)-Danpregna-5 (Z), 7(E), 10(19)-triene;

[0021] 1(S), 3(R)-Dihydroxy-20(R)-(6'-Methyl-1'-heptyl)-9,10-Seppregna-5(Z), 7(E), 10(19)-triene;

[0022] 1(S), 3(R)-dihydroxy-20(S)-(5'-hydroxy-5'-methyl-1'-hexyloxy)-9,10-dihydroxy-5(Z) , 7(E),...

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Abstract

The present invention relates to a pharmaceutical composition for dermal use, said composition comprising a first pharmacologically active component A consisting of at least one vitamin D or vitamin D analogue and a second pharmacologically active component B consisting of at least one corticosteroid.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition for the skin comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid. In particular, the present invention relates to pharmaceutical compositions containing two or more pharmacologically active compounds having low compatibility due to their respective optimum stable pH values, said pharmacologically active compounds being preferably at least one vitamin D analogs and at least one corticosteroid. Background of the invention [0002] In diseases treated by dermal administration, such as psoriasis, it is often desirable to employ a combination therapy comprising two or more different pharmacologically active compounds. Thus, in the treatment of, for example, psoriasis, it is relatively common to employ a combination therapy comprising a steroid compound, such as a corticosteroid, and a vitamin D analog, such as calcipotriol, wherein each active compound is f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61KA61K9/10A61K9/14A61K31/41A61K31/44A61K31/56A61K31/573A61K31/58A61K31/59A61K31/593A61K47/10A61K47/14A61K47/32A61PA61P17/06C07C
CPCA61K31/59A61K47/06A61K31/593A61K31/573A61K47/10A61K9/0014A61K31/56A61P17/00A61P17/06A61P17/08A61P3/02A61P31/10A61P43/00A61K2300/00
Inventor E·迪德里克森G·霍伊
Owner LEO PHARMA PROD LTD AS LOVENS CHEM FAB PRODUKTIONS AS
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