Absorbable artificial dura meter of brain and its preparing process

A technology of artificial dura mater and dura mater, which is applied in the field of preparation of layered structure products, can solve the problems of inability to process mesh scaffolds, fibrosis, brain adhesion, etc., and achieve good biocompatibility, absorbability, and degradation speed Slow down and lighten the effect of inflammatory response

Inactive Publication Date: 2004-06-30
李建民 +6
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] In recent years, some people have used bovine pericardium and pig peritoneum as substitute materials for dura mater, but they are all heterogeneous tissues, and the residual antigens will lead to different degrees of inflammatory reactions, resulting in fibrosis and brain adhesions
Others have made silicone rubber polyester membranes, silicone nylon membranes, and single-sided silicon silk membranes. Although these biomaterials have good biocompatibility, they exist in the body for a long time and can form fiber packages, which may cause cancer by the membrane.
Some people also make artificial dura mater with short carbon fiber and chitosan. The biofilm has good compatibility and can be partially absorbed. (Chinese Journal of Neurosurgery, 1985.11: 102. Chinese Journal of Neurosurgery 1989, 5, 2: 135. Chinese Journal of Neurosurgery 1998, 36, 6: 379, Chinese Journal of Neurosurgery 1997, 13, 4: 236)

Method used

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  • Absorbable artificial dura meter of brain and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The Vicryl net is placed on the glass plate of the horizontal mould, and after flattening, the prepared 3% chitosan mixed solution containing a small amount of glycerin, gelatin, norfloxacin (chitosan powder 320 orders, deacetylation degree 85%, 30 grams, dissolved in 1000 ml of 1% glacial acetic acid solution, fully stirred and dissolved to make 3% chitosan solution, left to stand for 24 hours, took its filtrate, then added 5 ml of glycerin, 30% 7 milliliters of gelatin, 3 grams of norfloxacin, stir well to get chitosan solution. Pour into the surface of the Vicryl net, flatten the horizontal salivation, its thickness is 2-6 mm, put it in a drying oven at 40 ° C for 24 Take it out from the mold after 1 hour, put it in 5% sodium hydroxide solution and soak it for 1 hour, then rinse it with distilled water, soak it for 1 hour, take it out, flatten it at 40°C and put it in a drying oven at 40°C for 2 hours Serve as artificial dura mater, its thickness is 0.03 millimeters,...

Embodiment 2

[0024] In order to be suitable for mechanized industrial production, the horizontal salivation method of embodiment 1 can be replaced by the horizontal spraying method, that is, the material of the polylactic acid net is woven into a polylactic acid weaving cloth of 80 × 1000 centimeters, and it is placed on a horizontal platform after being flattened. The method of embodiment 1 is configured into 3% chitosan mixed solution, carries out horizontal spraying with the coating spray head that American Nuoyan letter company produces, and its thickness is controlled by computer to be 3 millimeters, obtains 0.20 millimeters thick composite film after drying, then use embodiment The artificial composite film can be obtained by neutralizing, washing, drying, cutting, packaging, and γ-ray disinfection according to the method of 1. It can be used for the repair of abdominal wall defect.

Embodiment 3

[0026]First spray the copolymer of lactic acid and glycolic acid (90:10 molar ratio) on the surface of the non-woven fabric coating drum at high temperature (300°C) and high pressure (400 atmospheres) to make polylactic acid non-woven fabric, and then use The prepared 3% chitosan mixed solution of embodiment 1 is poured on the surface of the non-woven fabric, and the horizontal salivation is flattened, and after being dried in a drying oven at 40°C, the artificial dura mater is formed, the thickness is 0.30 mm, and the dry film strength is 120Mpa, the wet film strength is 80Mpa, the water absorption rate is 160%, the seam tension is 700 grams, and the water permeability rate is 0.

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Abstract

An absorbable artificial dura mater of brain is prepared from glycerin, gelatin and the mixed solution of norfloxacin and 3% chitosan through coating the mixture on polylactate net or non-woven cloth by horizontal doctor blading or spraying, baking, neutrlizing, flushing with distilled water, immersion, drying cutting and sterilization to obtain a dual-layer artificial dura mater of brain. Its advantages include high biocompatibility, no poison, no antagon reaction and slow absorption. It can be used to repair human organs.

Description

technical field [0001] The invention belongs to a preparation method of a layered structure product, more specifically, a preparation method of a composite layer structure material for human dura mater defect repair. Background technique [0002] The human dura mater is an important barrier to protect the brain and prevent the communication between cerebrospinal fluid and the outside world, often due to complications such as open craniocerebral injury (industry, traffic, war, etc.), tumor erosion, and intracranial infection. In addition, when the dura mater is defective, it will inevitably cause adhesions around the brain tissue, often causing diseases such as epilepsy, headache, and brain dysfunction. [0003] At present, the dural defect repair materials used by medical institutions at home and abroad can be roughly divided into: absorbable grafts (including autologous and allogeneic) such as temporalis muscle fascia, skull periosteum, fascia lata, fibrin membrane, allanto...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61L27/00
Inventor 陶智潞张保军李建民
Owner 李建民
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