Polypeptide synthesizer for preparing thymalfasin raw material

Abstract

The invention belongs to the technical field of thymalfasin preparation, and discloses a polypeptide synthesizer for thymalfasin raw material preparation, which comprises a rack, a base is arranged below the rack, a storage tray is arranged at the top end of the rack, a material injection assembly is arranged on the right side of the top end of the storage tray, and a workbench is arranged on the outer side surface of the material injection assembly. And an extension frame is fixedly mounted at the front end of the workbench. After the system is started, manual assistance is not needed, the situation that multiple electromagnetic valves need to be used for controlling injection of amino acid in a traditional device is avoided, the use cost is reduced, meanwhile, the possibility of sequential injection errors is reduced, meanwhile, injection of all amino acid is completed only through a single suction channel, and the production efficiency is improved. The problem that each amino acid in a traditional device needs to be connected through a pipeline is solved, the pipeline connecting process is avoided, meanwhile, the pipeline disorder phenomenon caused by multiple pipelines is avoided, the use convenience is improved, and the use cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of new preparation of thymus method, in particular to a polypeptide synthesizer for preparing new raw materials of thymus method. Background technique [0002] Thymosin is a chemically synthesized polypeptide consisting of twenty-eight amino acids. Its properties are white or off-white powder or loose lumps. It is mainly used for chronic hepatitis B and as a vaccine for immune-compromised patients to enhance immune response. The principle of common peptide synthesizers is to use solid-phase synthesis as the reaction principle. In a closed explosion-proof glass reactor, the amino acids are made in a known order (sequence, generally from C-terminal-carboxy-terminal to N-terminal-amino-terminal) is continuously added, reacted and synthesized, and the operation finally obtains a polypeptide carrier, that is, multiple amino acids are sequentially added, reacted and synthesized to finally obtain thymosin. [0003...

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Problems solved by technology

[0003] During the synthetic process of thymofaxin using a peptide synthesizer, since thymofaxin needs to use 28 kinds of amino acids for synthesis, and each amino acid needs to be placed in a different storage tank, it is necessary to use The twenty-eight storage tanks are all placed on the peptide synthesizer and connected with the peptide synthesizer using pipelines, and the output end of each pipeline is equipped with a solenoid valve for the input of amino acids, resulting in , the connection of pipelines is extremely complicated, and the number of pipelines is large and prone to confusion, and each pipeline needs to be installed with a corresponding solenoid valve, resulting in a significant increase in cost of use, high cost of use, and low convenience

[0004] In the process of polypeptide synthesis, some dripping will occur during the absorption of amino acids, and the solvent used for the reaction will also drip, resulting in a certain amount of waste liquid during use. In the prior art Usually, a waste liquid tank is provided to receive the waste liquid, but the capacity of the waste liquid tank is limited. During the new preparation process of the thymus method, due to the large number of amino acids involved, the waste liquid is produced in a large amount during the preparation process. In the prior art, after running for a period of time, it is necessary to stop the machine to discharge the waste liquid tank, which cannot realize regular automatic waste discharge, resulting in low use efficiency

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