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Cell culture chip

A cell culture and chip technology, applied in tissue cell/virus culture devices, material stimulation analysis, laboratory containers, etc., can solve problems such as interference, achieve the effect of increasing volume and ensuring the effectiveness of detection

Pending Publication Date: 2022-08-02
INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the usual microfluidic chip materials have strong Raman signals, which will seriously interfere or even completely mask the Raman signals of weaker cells. At the same time, there are still problems on how to fix / stabilize the moving cells in the solution for Raman detection. question

Method used

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  • Cell culture chip
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Embodiment Construction

[0034] The following describes in detail the embodiments of the present application, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary, and are intended to be used to explain the present application, but should not be construed as a limitation to the present application.

[0035] A cell culture chip for Raman in situ detection, such as figure 1 As shown, including: a quartz substrate 1;

[0036] The cover plate 6 is covered above the quartz substrate 1 , and there is a gap between the cover plate 6 and the upper surface of the quartz substrate 1 , and a cell culture cavity is formed in the gap. Specifically, as figure 1 As shown, the cover plate 6 is also provided with a culture solution inlet 7 and a culture solution outlet 8, s...

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Abstract

A cell culture chip includes: a quartz substrate; the cover plate is arranged above the quartz substrate in a covering manner, a gap is formed between the cover plate and the upper surface of the quartz substrate, and a cell culture cavity is formed in the gap. The cover plate and the quartz substrate are arranged to have a certain distance, so that the influence of the cover plate on a spectral signal is reduced, and meanwhile, the space between the cover plate and the quartz substrate is arranged as the cell culture cavity, so that cell culture and / or fixation can be performed in the space, and in-situ detection and analysis of cells can be conveniently carried out.

Description

technical field [0001] The present application relates to a cell culture chip, in particular to a microfluidic chip that can be used for cell culture and detection at the same time. Background technique [0002] Microbes play a vital role in driving elemental biogeochemical cycles and maintaining ecosystem balance. However, due to the active and complex and diverse dynamic life activities of microorganisms, people's understanding of them is still very insufficient. Microorganisms can not only produce sensitive stress responses to changing environments, which is an important mechanism for their adaptive evolution and survival, but also have a variety of different functions and undergo very active temporal dynamic changes in the exercise of functions, such as metabolites exchange with nutrients. Taking nitrogen-fixing cyanobacteria as an example, it also has fixed nitrogen (N 2 ) and fixation of carbon dioxide (CO 2 ) ability, this process can be completed by different cel...

Claims

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Application Information

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IPC IPC(8): C12M3/00B01L3/00G01N21/65
CPCC12M23/16C12M23/34B01L3/502761G01N21/65B01L2300/0861B01L2200/10
Inventor 崔丽辛雨菡杨凯朱永官
Owner INST OF URBAN ENVIRONMENT CHINESE ACAD OF SCI
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