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Composite piezoelectric film for inducing bone regeneration as well as preparation method and application of composite piezoelectric film

A piezoelectric film and bone regeneration technology, applied in the field of medical materials, can solve problems such as changes in bone repair materials, achieve the effects of accelerating bone regeneration, improving anti-inflammatory effects, and facilitating large-scale production

Active Publication Date: 2022-07-29
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the above technical deficiencies, provide a composite piezoelectric film for inducing bone regeneration and its preparation method and application, and solve the technical problem that bone repair materials in the prior art cannot be changed with changes in the physiological environment

Method used

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  • Composite piezoelectric film for inducing bone regeneration as well as preparation method and application of composite piezoelectric film
  • Composite piezoelectric film for inducing bone regeneration as well as preparation method and application of composite piezoelectric film
  • Composite piezoelectric film for inducing bone regeneration as well as preparation method and application of composite piezoelectric film

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preparation example Construction

[0028] The invention provides a simple, efficient and stable preparation method of a composite piezoelectric film for inducing bone regeneration, which overcomes the problems of poor biocompatibility of other bone repair materials and the inability to biomimulate the electrochemical microenvironment around natural bone tissue.

[0029] The preparation method of the present invention comprises the following steps:

[0030] 1. Prepare 100 mL of 10 mM tris solution, add an appropriate amount of dilute hydrochloric acid, and adjust the pH to 8-9;

[0031] 2. Weigh a certain amount of graphene oxide and dopamine hydrochloride, and add them to the tris solution prepared above, and ultrasonically disperse them uniformly. The ultrasonically dispersed solution was uniformly stirred at a constant temperature for a period of time, and then vacuum-dried overnight to obtain the prepared GO-PDA particles;

[0032] 3. Weigh a certain mass of the prepared GO-PDA particles, add them into an o...

Embodiment 1

[0048] Prepare 100 mL of 10 mM tris solution, adjust the pH to 8.5 with dilute hydrochloric acid, add 10 mg of GO and 20 mg of dopamine hydrochloride, ultrasonically disperse for 1 h, then uniformly stir at 60 °C for 48 h, and finally put the mixed solution into a vacuum of 80 °C Dry oven overnight. The prepared GO-PDA powder was dispersed in dichloromethane to prepare a 2 mg / mL GO-PDA dispersion. 1 g of PVDF was weighed and dissolved in 10 mL of dichloromethane, and then 1.5 mL of GO-PDA dispersion was added to the PVDF solution and stirred for 5 hours. After the stirring was complete, the solution was transparent, and the solution was spread on a glass plate and dried in a vacuum drying oven at 70° C. overnight. The next day, the dried films were annealed at 90 °C for 2 h. After the annealing is complete, the film is peeled off to a thickness of 60 μm. Finally, corona polarization was carried out at 10kv for 30min. After waiting for polarization, the composite piezoelect...

Embodiment 2

[0050] Prepare 100 mL of 10 mM tris solution, adjust the pH to 8.5 with dilute hydrochloric acid, add 10 mg of GO and 50 mg of dopamine hydrochloride, ultrasonically disperse for 1 h, then uniformly stir at 60 °C for 48 h, and finally put the mixed solution into a vacuum of 80 °C Dry oven overnight. The prepared GO-PDA powder was dispersed in dimethyl sulfoxide to prepare a 3 mg / mL GO-PDA dispersion. 1 g of P(VDF-TrFE) was weighed and dissolved in 15 mL of dimethyl sulfoxide, and 2.5 mL of GO-PDA dispersion was added to the P(VDF-TrFE) solution and stirred for 6 hours. After the stirring was completed, the solution was spread on a glass plate and dried in a vacuum drying oven at 60°C overnight. The next day, the dried films were annealed at 100 °C for 2 h. After the annealing is complete, the film is peeled off to a thickness of 60 μm. Finally, corona polarization was carried out at 15kv for 60min. After waiting for polarization, the composite piezoelectric film can be pre...

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Abstract

The invention relates to a composite piezoelectric film for inducing bone regeneration and a preparation method and application thereof, and the preparation method comprises the following steps: (1) taking GO-PDA dispersion liquid, adding the GO-PDA dispersion liquid into a piezoelectric polymer solution, and uniformly stirring the GO-PDA dispersion liquid and the piezoelectric polymer solution to obtain a mixed solution; wherein the GO-PDA dispersion liquid is obtained by adding GO-PDA particles into an organic solvent I; the mass ratio of the GO-PDA particles to the piezoelectric polymer is (2-12.5) mg: (1-3) g; and (2) forming the mixed solution into a film through a solvent tape casting method, drying, and sequentially carrying out annealing treatment and corona polarization treatment to obtain the composite piezoelectric film for inducing bone regeneration. The composite piezoelectric film adopts a solvent tape casting method, and is convenient for large-scale production; and the prepared membrane is uniform, has toughness and excellent mechanical properties, meets the mechanical strength after being implanted in vivo, and recovers the electrical microenvironment of cells, so that the bone marrow mesenchymal stem cells are differentiated into osteoblasts.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a composite piezoelectric film for inducing bone regeneration and a preparation method and application thereof. Background technique [0002] Diabetes mellitus (DM) is a chronic metabolic disease affecting 387 million people worldwide in 2020, and the number of people with diabetes is expected to exceed 590 million by 2035. DM increased the risk of fracture from 20% to 300%, in addition to a marked decrease in bone repair capacity under high glucose conditions. Therefore, the incidence of nonunion and delayed union of fractures in diabetic patients is much higher than that in normal patients. Therefore, there is an urgent need to establish effective methods to promote bone repair in diabetic patients. However, the currently used bone repair materials cannot meet the clinical needs. The main reason is that the current bone repair materials can only simulate the physi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/02A61L27/54
CPCA61L27/025A61L27/18A61L27/16A61L27/54A61L2430/02A61L2300/10A61L2300/216A61L2300/412A61L2300/41C08L79/04C08L27/12Y02A50/30
Inventor 樊李红张岑岑舒展褚莹莹彭才兴
Owner WUHAN UNIV OF TECH
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