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Composition for balancing skin microbiome and improving acne, containing centella asiatica cultivated with lava seawater as active ingredient

A technology of active ingredients and lava sea water, which can be applied in drug combinations, skin diseases, skin care preparations, etc., can solve the problems of undisclosed skin microbiome, and achieve the effect of enhancing the balance of skin microbiome and improving acne

Pending Publication Date: 2022-07-29
AMI COSMETIC CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, so far, there is no relevant research or literature that discloses whether Centella asiatica extract can be used to maintain the balance of skin microbiome instead of simply inhibiting harmful bacteria in the skin and promoting the growth of beneficial bacteria

Method used

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  • Composition for balancing skin microbiome and improving acne, containing centella asiatica cultivated with lava seawater as active ingredient
  • Composition for balancing skin microbiome and improving acne, containing centella asiatica cultivated with lava seawater as active ingredient
  • Composition for balancing skin microbiome and improving acne, containing centella asiatica cultivated with lava seawater as active ingredient

Examples

Experimental program
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Effect test

Embodiment 1

[0077] Manufacture of Centella asiatica extract and Paeonia lactiflora extract

[0078] Centella asiatica seedlings (JOYPLANT, seedling length 100-120 mm) or peony (Paeonia lactiflora) seedlings (Gumsan Seedlings Agricultural Garden, seedling length 70-90 mm) were transplanted to a mixed bed soil (Agriculture In the cultivation frame of NONGWOOBIO Co., Ltd., in order to promote growth, a plastic film is covered and a awning is installed, and a liquid fertilizer containing fresh water (tap water) or desalinated lava seawater (hardness of 100) is sprayed every 2 days for a total of Cultivated for 2, 4 or 6 weeks. After adding 20 times the weight of 70% ethanol to the dried powder of the cultivated Centella asiatica (whole plant) or Paeonia lactiflora (whole plant) to carry out the extraction for 24 hours, the filtrate was filtered with filter paper, and the filtrate was then depressurized. Concentrated and freeze-dried to obtain Centella asiatica or Paeonia lactiflora 70% ethan...

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Abstract

The present invention relates to a composition for balancing skin microbiome and improving acne, which comprises an extract of centella asiatica cultivated with lava seawater as an active ingredient, and a use thereof. The centella asiatica extract, to which the present invention is applied, can be cultivated using desalted lava seawater to avoid cytotoxicity, can inhibit NO production in cells and exhibit anti-inflammatory activity, and also has an effect of improving acne skin and even improving skin microbiome balance. Therefore, the composition can be effectively used as a composition for improving skin microbiome balance. In particular, the composition can further enhance the skin microbiome balance improving effect by additionally containing the Paeonia lactiflora extract.

Description

technical field [0001] The present invention relates to a skin microbiome balance and an acne-improving composition comprising an extract of Centella asiatica cultivated using lava seawater as an active ingredient, and use thereof. Background technique [0002] Recently, the prevalence of skin diseases is increasing dramatically due to complex factors such as genetic factors, environmental factors, skin barrier abnormalities, immunological abnormalities, or changes in diet and lifestyle. Among many skin diseases, acne is caused by a combination of factors such as hyperkeratosis of the follicle wall, increased cortical secretion or inflammation. [0003] One of the main causes of acne is the presence of bacteria on the skin. Common skin bacteria that induce skin inflammation include the term gram-positive bacteria Bacillus subtilis, Staphylococcus aureus or Propionibacterium acnes and the Gram-negative bacteria Escherichia coli (Escherichia coli) or Pseudomonas aeruginosa (...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61Q17/00A61P17/10A61P31/04A23L33/105
CPCA61K8/9789A61Q19/00A61Q17/005A61P17/10A61P31/04A23L33/105A61K2800/5922A61K2800/92A23V2002/00A23V2200/318
Inventor 李境录金京珉金秀颖姜芝美申素荣姜炫圭李圣铉崔昊旻李宗泽赵美金裕根玄承勋金智荣
Owner AMI COSMETIC CO LTD
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