Method, device and equipment for generating active peptide fragment and storage medium

Abstract

The invention is applicable to the field of biological medicine, and provides a method, device and equipment for generating an active peptide fragment and a storage medium, and the method comprises the following steps: obtaining a peptide fragment generation model corresponding to specific activity, the peptide fragment generation model is obtained by training an LSTM network by using a general peptide data set and a preset active peptide data set corresponding to the specific activity, the universal peptide data set comprises a plurality of universal peptide fragments; and generating a plurality of peptide fragments with specific activity by using the peptide fragment generation model. In the scheme, the peptide fragment generation model is obtained by training the LSTM network by using the general peptide data set and the preset active peptide data set corresponding to the specific activity, and can learn potential characteristics in the general peptide fragment and potential activity rules in the known active peptide fragment in the training process, so that the potential activity of the active peptide fragment is improved. Therefore, in the process of actually using the peptide fragment generation model, the peptide fragments with different specific activities and abundant diversity can be generated according to different specific activity requirements.

Description

technical field [0001] The present application belongs to the field of biomedicine, and particularly relates to methods, devices, equipment and storage media for generating active peptide fragments. Background technique [0002] In recent years, many bioactive peptides have shown effective therapeutic effects against a variety of complex diseases, such as antiviral, antibacterial and anticancer active peptides. And a variety of peptide drugs have been approved for the treatment of various diseases, such as diabetes, cancer, osteoporosis, multiple sclerosis, human immunodeficiency virus (HIV) infection and chronic pain, etc. effective results. Therefore, research on active peptides is very necessary. [0003] In the prior art, new active peptides are mainly searched by randomly mutating existing peptides, and then new active peptides are searched in the mutated existing peptides. This method is too blind to directly generate peptides with specific activities, and the diver...

AI Technical Summary

Problems solved by technology

[0004] In view of this, the embodiments of the present application provide methods, devices, equipment, and storage media for generating active peptides to solve the problems in the prior art that peptides with specific activities cannot be directly generated and the diversity of peptides is insufficient

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