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Nest and fissure sealing agent and preparation method thereof

A pit and fissure sealing and diluent technology, which is used in pharmaceutical formulations, dental preparations, compression mold cups, etc., can solve the problems of inability to release effective substances for a long time, poor biocompatibility, and unadjustable degradation, and is not easy to deform or slip. , the effect of strong pH-responsive release, excellent mechanical properties

Active Publication Date: 2022-07-12
成都爱睿康乐医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary inorganic fillers have poor dispersion, poor fluidity, and poor biocompatibility
Moreover, the degradation of ordinary inorganic fillers cannot be adjusted, resulting in the inability of pit and fissure sealants to release effective substances for a long time in the oral cavity

Method used

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  • Nest and fissure sealing agent and preparation method thereof
  • Nest and fissure sealing agent and preparation method thereof
  • Nest and fissure sealing agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A preparation method of pit and fissure sealant, comprising the following preparation steps:

[0057] (1) Weigh and add 35 parts of bisphenol A glycerol dimethacrylate, 40 parts of diluent (triethylene glycol dimethacrylate) and inorganic filler (fumed silica) in sequence in a stirring tank 5 parts, stirring at 500r / min for 30min to obtain the first material;

[0058] (2) 20 parts of modified bioactive glass and 2 parts of photoinitiator (diphenyliodonium hexafluorophosphate) were weighed in turn and added to the first material, stirred at 800r / min for 30min, and then irradiated with a light curing machine for 20s After curing, the sample of Example 1 was obtained.

[0059] Wherein, the modified bioactive glass is prepared by the following method:

[0060] (1) Preparation of MBGS: MBGS (bioactive glass) was prepared by a modified sol-gel method by using DDA (dodecylamine) as a catalyst and template. The molar composition of MBGS is 80% SiO 2 , 16%CaO and 4%P 2 O 5...

Embodiment 2

[0068] A preparation method of pit and fissure sealant, comprising the following preparation steps:

[0069] (1) Weigh and add 40 parts of bisphenol A glycerol dimethacrylate, 35 parts of diluent (triethylene glycol dimethacrylate) and inorganic filler (fumed silica and Titanium dioxide is mixed in any proportion) 5 parts, and stirred at 600r / min for 45min to obtain the first material;

[0070] (2) 17 parts of modified bioactive glass and 2 parts of photoinitiator (camphorquinone) were weighed into the first material in turn, stirred at 900r / min for 45min, and then irradiated with a light curing machine for 20s to complete curing, that is, the embodiment was obtained. 2 samples.

[0071] Wherein, the modified bioactive glass is prepared by the following method:

[0072] (1) Preparation of MBGS: MBGS (bioactive glass) was prepared by a modified sol-gel method by using DDA (dodecylamine) as a catalyst and template. The molar composition of MBGS is 80% SiO 2 , 16%CaO and 4%P ...

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Abstract

The invention discloses a pit and fissure sealing agent and a preparation method thereof. The pit and fissure sealing agent comprises 25-45 parts of bisphenol A glycerol dimethacrylate, 20-40 parts of a diluent, 15-20 parts of modified bioactive glass and 2-10 parts of an inorganic filler. And 1-5 parts of a photoinitiator. Wherein the used modified bioactive glass is prepared by the following steps: modifying bioactive glass comprising 80% of SiO2, 16% of CaO and 4% of P2O5 by using aminopropyltriethoxysilane as a coupling agent, modifying by using hyaluronic acid, and grafting by using dopamine-conjugated dialdehyde-hyaluronic acid. The modified bioactive glass is added into a resin basic formula to prepare the pit and fissure sealing agent so as to achieve better mechanical properties, meanwhile, the capacity of the pit and fissure sealing agent for responding to release ions according to pH changes is improved, and remineralization is expected to be promoted to achieve long-acting caries prevention.

Description

technical field [0001] The invention relates to a preparation method of a pit and fissure sealant and a pit and fissure sealant prepared by the preparation method, belonging to the field of medical biological materials. Background technique [0002] Dental caries is one of the most common diseases of the oral cavity, and its occurrence is often accompanied by problems of pain, chewing, aesthetics and communication barriers, affecting the normal life of patients. The incidence of pit and fissure caries accounts for 80-90% of the incidence of juvenile caries. This is because the tooth surface at the pit and fissure has a complex shape, which is easy to accumulate food residues, cause dental plaque to adhere, and is difficult to be cleaned. Therefore, it is necessary to focus on prevention. The occurrence of pit and fissure caries. The pit and fissure sealing technique has been used since the 1960s. After decades of research and clinical practice, the pit and fissure sealing t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/17A61K6/62A61K6/71A61K6/836A61K6/898
CPCA61K6/17A61K6/836A61K6/62A61K6/71A61K6/898C08B37/0072
Inventor 杨鸣威冯弘
Owner 成都爱睿康乐医疗器械有限公司
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