Application of ceramide combined osteoclast surface CD300lf receptor in preparation of medicine for treating periodontitis

A technology of osteoclast and ceramide, applied in the field of bone homeostasis of periodontitis, can solve problems affecting periodontitis and achieve the effect of slowing down the progress

Pending Publication Date: 2022-07-08
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, in the microenvironment of periodontitis, whether exogenous ceramide can affect the occurrence and development of periodontitis by binding to the CD300lf receptor on the surface of osteoclasts remains to be elucidated

Method used

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  • Application of ceramide combined osteoclast surface CD300lf receptor in preparation of medicine for treating periodontitis
  • Application of ceramide combined osteoclast surface CD300lf receptor in preparation of medicine for treating periodontitis
  • Application of ceramide combined osteoclast surface CD300lf receptor in preparation of medicine for treating periodontitis

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Embodiment Construction

[0037] The present invention adopts the meaning of abbreviation as follows:

[0038] CD300lf CD300 molecule-like family memberf Ceramide Ceramide BMMs bone marrow mononuclear cells M-CSF macrophage colony stimulating factor RANKL nuclear kappa B ligand receptor activator TRAP tartrate-resistant acid phosphatase ITIMs immunoreceptor tyrosine inhibitory motif NFATc1 osteoclast activated T cell nuclear factor μCT microcomputer tomography PC dipalmitoylphosphatidylcholine

[0039] In order to express the technical solutions of the present invention more clearly, the following further description is given in conjunction with specific embodiments, but cannot be used to limit the present invention, which are only some embodiments of the present invention.

[0040] 1. Materials

[0041] 1.1 Main experimental instruments

[0042]

[0043]

[0044] 1.2 Main reagents and consumables

[0045]

[0046...

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Abstract

The invention relates to the field of periodontitis bone homeostasis, in particular to application of a ceramide combined osteoclast surface CD300lf receptor in preparation of a medicine for treating periodontitis. According to the application disclosed by the invention, in a mouse periodontitis microenvironment, the expression of CD300lf on the surface of an osteoclast precursor is obviously reduced compared with that of a control group; the osteoclast precursor induces osteoclast differentiation in vitro, and CD300lf expression is reduced; under the stimulation of RANKL, the osteoclast differentiation capability of the osteoclast precursor with the CD300lf knocked out is obviously enhanced; the Ceramide ligand can be used for inhibiting the differentiation of an osteoclast precursor; the Ceramide ligand can be used for promoting the expression of CD300lf in periodontitis of mice and inhibiting bone resorption and osteoclast differentiation. The invention clarifies a new mechanism for inhibiting osteoclast differentiation by down-regulating CD300lf in a periodontal microenvironment, and the research is expected to provide a new target and a new idea for periodontal treatment.

Description

technical field [0001] The invention relates to the field of periodontitis bone homeostasis, in particular to the application of a ceramide-binding CD300lf receptor on the surface of osteoclasts in the preparation of a medicine for treating periodontitis. Background technique [0002] The maintenance of bone tissue homeostasis depends on the balanced activity of osteoblasts and osteoclasts. Osteoclast hyperactivation, bone homeostasis imbalance, and alveolar bone resorption caused by pathogenic bacteria and host immune responses in the periodontal microenvironment are one of the hallmarks of the progression of periodontitis. At present, the mechanical removal of plaque and calculus is mainly used clinically to slow down the resorption of alveolar bone. However, some patients still cannot obtain stable curative effect, which is manifested by the continuous progress of bone loss. Preventing and blocking alveolar bone loss is the key to the treatment of periodontal disease. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/164A61P1/02A61P29/00
CPCA61K45/00A61K31/164A61P1/02A61P29/00
Inventor 王茜杨乐
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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