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Application of alpinia zerumbet essential oil

A technology of ginger essential oil and uses, which is applied in the field of medicine to achieve the effects of improving biological activity, long half-life, and reducing toxicological safety and toxicity

Active Publication Date: 2022-06-28
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of alpinia zerumbet essential oil
  • Application of alpinia zerumbet essential oil
  • Application of alpinia zerumbet essential oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Collect the dried and mature fruits of Alpinia zerumbet (Pers.) Burtt.et Smith from Yunnan, and dry them in a cool and dry place. Pharmacopoeia standard sieve No. 3 sieve. Put the sample into a round-bottomed flask, add 8 times the amount of pure water, stir and mix, soak for 1 hour and extract by steam distillation for 7 hours at a temperature of 60-70 °C. Collect the distillate, add a small amount of ethyl acetate to extract 3 times, then add anhydrous sodium sulfate to remove water, let stand overnight to volatilize the ethyl acetate, and separate the anhydrous sodium sulfate to obtain the essential oil of Ginger japonica with a yield of 0.83%. Analyzed by gas chromatography-mass spectrometry and searched with Nist.14 spectral library to determine the components in the essential oil of Ginger (Table 1). 64 compounds were identified in the essential oil of Ginger, accounting for 98.14% by mass. The compounds with higher content were β-thujene (>18%), β-pinene (>17%), ...

Embodiment 2

[0043] The dried and mature peel of Alpinia zerumbet (Pers.) Burtt.et Smith produced in Yunnan was collected and dried in a cool and dry place. Pharmacopoeia standard sieve No. 3 sieve. Put the sample into a round-bottomed flask, add 8 times the amount of pure water, stir and mix, soak for 1 hour and extract by steam distillation for 7 hours at a temperature of 60-70 °C. Collect the distillate, add a small amount of ethyl acetate to extract 3 times, then add anhydrous sodium sulfate to remove water, let stand overnight to volatilize the ethyl acetate, and separate the anhydrous sodium sulfate to obtain the essential oil of Ginger japonica with a yield of 1.61%. Analyzed by gas chromatography-mass spectrometry and searched with Nist.14 spectral library to determine the components in the essential oil of Ginger (Table 2). 51 compounds were identified in the essential oil of Ginger pericarp, accounting for 91.23% by mass, among which the compounds with higher content were eucaly...

Embodiment 3

[0049] The dried and mature seeds of Alpinia zerumbet (Pers.) Burtt.et Smith from Yunnan were collected and dried in a cool and dry place. Pharmacopoeia standard sieve No. 3 sieve. Put the sample into a round-bottomed flask, add 8 times the amount of pure water, stir and mix, soak for 1 hour and extract by steam distillation for 7 hours at a temperature of 60-70 °C. Collect the distillate, add a small amount of ethyl acetate for extraction 3 times, then add anhydrous sodium sulfate to remove water, let stand overnight to volatilize the ethyl acetate, and separate the anhydrous sodium sulfate to obtain the essential oil of Ginger japonica with a yield of 1.02%. Analyzed by gas chromatography-mass spectrometry and searched with Nist.14 spectral library to determine the components in the essential oil of Ginger (Table 3). Seventy-seven compounds were identified from the essential oil of Ginger chinensis seeds, accounting for 97.42% by mass, among which the compounds with higher ...

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Abstract

The invention discloses application of alpinia zerumbet essential oil. The application specifically refers to application of the alpinia zerumbet essential oil in preparation of drugs or health products for treating and preventing central nervous system diseases. It is found for the first time that the alpinia zerumbet essential oil can improve symptoms of animals with nervous system diseases such as epilepsy in a zebra fish in-vivo model, when the concentration of the alpinia zerumbet essential oil ranges from 1 microgram / ml to 6 microgram / ml, the anti-epilepsy treatment efficiency is increased along with increase of the concentration, concentration dependence is shown, and EC50 is 2.86 microgram / ml. The present invention has good lipid solubility, is easy to pass through the blood brain barrier, thus having the characteristics of increased or improved toxicological safety (i.e. Reduced toxicity), increased or improved metabolic stability, longer half-life or less side effects, while producing similar or increased biological activity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of an essential oil of Ginger japonica in the preparation of medicines or health products for treating and preventing nervous system diseases. Background technique [0002] Alpinia is the dry ripe fruit of Alpinia zerumbet (Pers.) Burtt.et Smith, a plant of the genus Alpinia in the ginger family. Yanshan Ginger has the functions of warming and drying dampness, promoting qi, relieving pain, and cutting malaria. It is mainly used to treat symptoms such as cold pain in confidants, fullness of chest and abdomen, indigestion, vomiting and diarrhea. . As a characteristic national medicinal material of Guizhou real estate, Yanshan Ginger is often used to treat diseases such as gastric ulcer. [0003] The volatile oil of Ginger is the effective active part of Ginger, which has a wide range of biological activities such as anti-inflammatory, antioxidant and inhibiting endothelial dysfunc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P25/00A61P25/28A61P25/08A61P25/22A61P25/18A61P25/24A61P31/04A61P29/00A61P33/06A61K8/92A61Q19/00A23L33/105
CPCA61K36/9062A61P25/00A61P25/28A61P25/08A61P25/22A61P25/18A61P25/24A61P31/04A61P29/00A61P33/06A61K8/922A61Q19/00A23L33/105A61K2800/10A23V2002/00A23V2200/322A23V2250/21Y02A50/30
Inventor 许敏黄娅婷冯阳
Owner KUNMING UNIV OF SCI & TECH
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