Application of hederagenin in preparation of drug rehabilitation drugs

A technology of helexin and medicine is applied in the application field of helexin for preparing drug detoxification medicine, can solve the problems of unsatisfactory withdrawal effect, large side effects and high relapse rate, and achieves recovery of normal physiological function, Low cost and improved effectiveness of institutional change

Pending Publication Date: 2022-06-03
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine detoxification is relatively easy, but there are still problems such as high relapse rate, large side effects, high price, and unsatisfactory withdrawal effect after drug intervention

Method used

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  • Application of hederagenin in preparation of drug rehabilitation drugs
  • Application of hederagenin in preparation of drug rehabilitation drugs
  • Application of hederagenin in preparation of drug rehabilitation drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The present invention can be better understood from the following examples.

[0026] First, a mouse model of acute morphine addiction was established: the mouse morphine Conditional Place Preference (CPP) model was used to jointly detect the mice's response in the black and white box experiment, involuntary jumping after withdrawal, and Changes in body weight, observe the effect of helexin on anti-morphine addiction in mice, and evaluate the improvement of helexin in anti-morphine addiction and its possible mechanism of action.

[0027] 1 Experimental material

[0028] 1.1 Experimental animals

[0029] 8-10-week-old healthy C57BL / 6J mice, male, weighing 18-22 g, SPF grade.

[0030] Free drinking and eating, the animal room was kept at a constant temperature (temperature 20±2°C), constant humidity (humidity 50±10%), and 12-hour circadian rhythm control was adopted indoors (8:00 in the morning-20:00 in the evening, light at 20:00- in the evening) 8:00 a.m. light and da...

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Abstract

The invention discloses application of hederagenin in preparation of drug rehabilitation drugs, the hederagenin has no addiction and toxic and side effects, and has very good curative effects in a morphine addiction formation period, a fading period after the use of morphine is stopped, an abstinence delay period and a relapse period when the hederagenin is exposed to a morphine condition again. Hederagenin is a compound monomer derived from a traditional Chinese medicine astragalus membranaceus, can be sold in the market instead of a controlled drug, and can act on a classical pathway of opioid drug addiction; in addition, through further mechanism research on the traditional Chinese medicine monomer provided by the invention, the curative effect is determined, the price is moderate, and the traditional Chinese medicine monomer has a good commercial prospect.

Description

technical field [0001] The invention relates to the field of drugs for detoxification, in particular to the application of helexin in preparing drugs for detoxification. Background technique [0002] Drug and controlled substance abuse is a major problem in today's world, causing great harm to individuals, families and countries. Statistics from the World Health Organization show that in recent years, the number of drug addicts has continued to increase, the number of deaths caused by addictive substances has continued to rise, and the types of addictive substances have been continuously updated. In the future, drug and drug addiction will become a serious problem. social problems. [0003] Ancient Chinese medicine has accumulated very rich and valuable experience in detoxification. Traditional Chinese medicine detoxification attaches great importance to overall treatment, emphasizes syndrome differentiation and treatment, and has a good role in eliminating protracted symp...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K45/06A61K31/485A61P25/36
CPCA61K31/56A61K45/06A61K31/485A61P25/36A61K2300/00
Inventor 吕志刚王倩刘青阳
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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