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Tilmicosin premix and preparation method thereof

A technology of tilmicosin and premix, applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve low bioavailability, gastric acid damage, loss of appetite, etc. problems, to achieve the effect of improving the treatment effect, simple and easy process, and simple process conditions

Pending Publication Date: 2022-05-20
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although tilmicosin has many advantages, it has a strong bitter taste. Oral administration is not only bitter but also irritating to the gastric mucosa.
The main preparation on the market is its phosphate, which is easily destroyed by gastric acid after oral administration, incomplete absorption, low bioavailability, and short half-life in vivo
In veterinary medicine, it is mainly administered by mixing materials. Since animals are prone to loss of appetite when they are sick, they cannot play a role in timely treatment of diseases.

Method used

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  • Tilmicosin premix and preparation method thereof
  • Tilmicosin premix and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0021] A kind of tilmicosin premix of the present embodiment and preparation method thereof, during preparation, comprises the following steps:

[0022] (1) Take by weighing 10.0% tilmicosin and 1.0% adenosine, stir evenly to obtain mixed powder;

[0023] (2) Take by weighing 20% ​​cellulose acetate phthalate, add water to make adhesive slurry, where the water consumption is 8 times of the quality of the enteric carrier material;

[0024] (3) Add the mixed powder of step (1) to the adhesive slurry, turn on the mixer, fully stir for 30min, and mix evenly;

[0025] 4) Add anhydrous glucose with a mass percentage of 69% to the mixture in step (3), stir well for 20 minutes to make a soft material, granulate, dry at 60°C for 6 hours, and pass through a No. 4 sieve to obtain the product.

Embodiment 2

[0027] A kind of tilmicosin premix of the present embodiment and preparation method thereof, during preparation, comprises the following steps:

[0028] (1) Take by weighing 20.0% tilmicosin and 2.0% probenecid in mass percentage, stir evenly to obtain mixed powder;

[0029] (2) Take by weighing an acrylic resin with a mass percentage of 35%, add water to make a bonding slurry, where the water consumption is 7 times of the quality of the enteric-coated carrier material;

[0030] (3) Add the mixed powder of step (1) to the adhesive slurry, turn on the mixer, fully stir for 30min, and mix evenly;

[0031] 4) Add lactose with a mass percentage of 43% to the mixture in step (3), stir well for 20 minutes to make a soft material, granulate, dry at 80°C for 4 hours, and pass through a No. 4 sieve to obtain the product.

Embodiment 3

[0033] A kind of tilmicosin premix of the present embodiment and preparation method thereof, during preparation, comprises the following steps:

[0034] (1) Take by weighing 30.0% tilmicosin and 5.0% phosphatidic acid-beta lactoglobulin complex, stir evenly to obtain mixed powder;

[0035] (2) Take carboxymethyl ethyl cellulose with a mass percentage of 50%, add water to make a bonding slurry, where the water consumption is 10 times the quality of the enteric carrier material;

[0036] (3) Add the mixed powder of step (1) to the adhesive slurry, turn on the mixer, fully stir for 30min, and mix evenly;

[0037] (4) Add 5% anhydrous glucose and 10% corn starch to the mixture in step (3), stir well for 20 minutes to make a soft material, granulate, dry at 70°C for 5 hours, and pass through No. 4 Sieve, that is.

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Abstract

The invention discloses a tilmicosin premix and a preparation method thereof. The tilmicosin premix comprises the following raw materials in percentage by mass: 10-30% of tilmicosin, 1-5% of a bitter receptor inhibitor, 20-50% of an enteric carrier material and 15-69% of a diluent, according to the tilmicosin premix provided by the invention, the medicine and the bitter receptor blocker are mixed, so that on one hand, the tilmicosin premix can compete for a bitter receptor with tilmicosin, and on the other hand, transmission of a bitter signal to the brain is blocked, the irritant bitter taste of the tilmicosin is covered, the taste of the tilmicosin is improved, the clinical use compliance is improved, and the tilmicosin premix is beneficial to ingestion of treated animals; the treatment effect of the veterinary drug is improved.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a tilmicosin premix and a preparation method thereof. Background technique [0002] Tilmicosin (Tilmicosin), the molecular formula is C 46 h 80 N 2 o 13 , the molecular weight is 869.15. Appearance is white powder, bitter in taste, easily soluble in methanol, acetonitrile, acetone; soluble in ethanol, propylene glycol; insoluble in water. Tilmicosin is a semi-synthetic macrolide antibiotic for livestock and poultry developed by Elanco in the 1980s. It has strong antibacterial activity and broad antibacterial spectrum, good tissue penetration, excellent pharmacokinetic characteristics, and no toxicity. Teratogenic, carcinogenic and mutagenic and other adverse reactions, it has inhibitory effect on all Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, spirochetes, etc., especially a variety of mycoplasma and spirochetes. The antibacteria...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/706A61K47/42A61K47/20A61K47/26A61K47/38A61K47/36A61K47/32A61P31/04
CPCA61K9/1658A61K9/1623A61K9/1652A61K9/1635A61K9/1617A61K31/706A61P31/04Y02A40/818
Inventor 吴东林
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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