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Application of recombinant human myeloid-derived growth factor in treatment of renal ischemia-reperfusion injury

A technology of renal ischemia-reperfusion and growth factors, applied in the field of medicine, can solve problems such as renal tissue damage, and achieve the effects of improving renal function, reducing renal protection and improving quality of life

Pending Publication Date: 2022-05-13
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Problems solved by technology

[0017] Researchers have confirmed that after 2 hours of renal ischemia-reperfusion, nuclear factor kappa-B (nuclear factor kappa-B, NF-κB) is activated in large quantities, mainly concentrated in the expression of renal tubular epithelial cells, thereby causing intercellular adhesion molecule-1 ( Intercellular cell adhesion molecule-1, ICAM-1), tumor necrosis factor α (tumor necrosis factor-α, TNF-α) expression, and then lead to renal tissue damage

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  • Application of recombinant human myeloid-derived growth factor in treatment of renal ischemia-reperfusion injury
  • Application of recombinant human myeloid-derived growth factor in treatment of renal ischemia-reperfusion injury
  • Application of recombinant human myeloid-derived growth factor in treatment of renal ischemia-reperfusion injury

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[0034] In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments These are some embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the drawings herein may be arranged and designed in a variety of different configurations.

[0035] Thus, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary ski...

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Abstract

The invention provides an application of a recombinant human myeloid-derived growth factor in preparation of a medicine for treating renal ischemia reperfusion injury. The recombinant human medullary-derived growth factor can reduce serum creatinine and urea nitrogen levels of mice suffering from renal ischemia reperfusion injury, improves renal functions after renal ischemia reperfusion injury, has a kidney protection effect and can relieve oxidative stress injury caused by renal ischemia reperfusion injury. The traditional Chinese medicine composition brings hopes for improving the life quality of kidney transplantation patients and prolonging the survival time of transplanted kidneys, and also has a certain far-reaching influence on prevention and treatment of ischemia reperfusion injuries of other tissues and organs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of recombinant human myeloid growth factor in the preparation and treatment of renal ischemia-reperfusion injury. Background technique [0002] In 1960, Jennings first proposed the concept of "ischemia-reperfusion injury (IRI)", that is, restoring blood supply to tissues and organs after ischemia not only fails to restore their functions and damaged structures, but also causes Its dysfunction and structural damage are further exacerbated by a phenomenon that can occur in a variety of organs. The kidney itself has a very rich blood supply and is very sensitive to ischemia-reperfusion injury. [0003] Due to the peculiarity of the kidney transplantation process, the current donors are mainly donors after circulatory death (DCD). The kidneys develop "warm ischemia" after the blood supply in the donor is cut off. During the subsequent storage period, the ...

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Application Information

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IPC IPC(8): A61K38/18C07K14/475A61P13/12
CPCA61K38/18C07K14/475A61P13/12
Inventor 丁小明王婧雯王颖郑瑾
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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