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Single-view-angle reflective near-infrared two-region fluorescence dynamic tomography system and method

A tomographic imaging and near-infrared technology, applied in the field of medical imaging, to achieve the effect of improving imaging spatial resolution, high sensitivity, and improving detection depth

Active Publication Date: 2022-05-13
XIDIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Aiming at the problems existing in the existing infrared first-region fluorescence tomography technology, the present invention provides a single-view reflection type near-infrared second-region fluorescence dynamic tomography system and method

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  • Single-view-angle reflective near-infrared two-region fluorescence dynamic tomography system and method
  • Single-view-angle reflective near-infrared two-region fluorescence dynamic tomography system and method
  • Single-view-angle reflective near-infrared two-region fluorescence dynamic tomography system and method

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Embodiment 1

[0056] In order to overcome the problems of infrared first-region fluorescence tomography technology, the present invention provides a single-view reflective near-infrared second-region dynamic fluorescence tomographic imaging, which has the characteristics of small scattering and high sensitivity, compared with the traditional near-infrared first-region Fluorescence tomography has the advantages of high imaging resolution and large imaging depth. In addition, the present invention has the advantage of single-view reflective imaging, combined with CT three-dimensional reconstruction, can obtain dynamic real-time dual-mode tomographic image information of a living body.

[0057] The invention provides a single-view reflection type near-infrared two-zone dynamic fluorescence tomographic imaging system, which includes: a fluorescence imaging module, a CT imaging module, a central control module, a data processing module and an auxiliary module.

[0058] The present invention sets...

Embodiment 2

[0064] The invention discloses a single-view reflection type near-infrared two-zone dynamic fluorescence tomographic imaging system, comprising: a fluorescence excitation module, a near-infrared two-zone fluorescence collection module, a CT imaging module, a data processing module and a central control module. The near-infrared two-zone fluorescence tomography in the present invention obtains optical data by irradiating the imaging organism with a wide-field light source and collecting reflective fluorescence. Combined with the structural image information obtained by CT imaging, an optical tomographic reconstruction mathematical model is established to reconstruct the imaging organism. The three-dimensional spatial distribution image of fluorescent probes in the second near-infrared region. Among them, CT imaging performs single-view transmission scanning on the object at the same time as fluorescence imaging, obtains a CT projection image, and obtains a three-dimensional CT s...

Embodiment 3

[0084] As a molecular imaging technology, near-infrared second-region imaging uses near-infrared second-region fluorescence with a wavelength of 1000nm-1700nm to image lesions. Compared with traditional near-infrared imaging, it has the advantage of high imaging resolution. Combining near-infrared second-region imaging technology with traditional structural imaging such as CT, and performing three-dimensional reconstruction of images through deep learning, can realize near-infrared second-region dynamic three-dimensional tomographic imaging of lesions, and more accurately locate biological lesions.

[0085] figure 1 It is a schematic structural diagram of a single-view reflective near-infrared two-zone dynamic fluorescence tomography system according to an embodiment of the present invention. Such as figure 1 As shown, the single-view reflective near-infrared second-zone dynamic fluorescence tomography system includes: a CT imaging module composed of an X-ray tube that emits...

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Abstract

The invention belongs to the technical field of medical imaging, and discloses a single-view-angle reflective near-infrared two-region fluorescence dynamic tomography system and method, and the system comprises a fluorescence imaging module, a CT imaging module, a central control module, a data processing module and an auxiliary module. The wide-field excitation light source is used for irradiating an imaging target, the collecting camera and the excitation light source are located on the same side, the imaging speed is greatly increased through reflection type imaging, and real-time fluorescence tomography can be obtained. According to the invention, near-infrared two-region imaging is adopted, so that the image resolution of three-dimensional reconstruction can be improved; a reflective fluorescence tomography technology is utilized, three-dimensional fluorescence tomography reconstruction is carried out only by using single-view-angle reflection fluorescence data, it is hopeful to achieve wide-field excitation to obtain high imaging speed, and real-time fluorescence tomography is obtained; the structure image of the sample is obtained by combining the single-view CT tomography technology of depth reconstruction, and the sample does not need to be rotated any more, so that the system complexity is reduced, and the imaging speed is improved at the same time.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and in particular relates to a single-view reflection type near-infrared two-zone fluorescence dynamic tomographic imaging system and method. Background technique [0002] At present, optical molecular imaging has been widely used in biomedical research and is expected to be extended to clinical diagnosis. Near-infrared fluorescence tomography technology injects targeted fluorescent probes, uses exogenous excitation light to excite fluorescent probes, and obtains the three-dimensional distribution of fluorescent probes in vivo by collecting fluorescence information. This non-invasive and non-invasive detection process can localize and quantify the lesion, and has the characteristics of high sensitivity. The combination of optical imaging technology and traditional imaging technologies such as CT can not only obtain the structural information of lesions, but also obtain molecular informat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B6/03
CPCA61B5/0073A61B5/0071A61B6/5235A61B6/032Y02B20/00
Inventor 曹旭马庆超白婷婷熊枭鲜浩楠王艺涵王忠良朱守平
Owner XIDIAN UNIV
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