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Exocarpium citri grandis extract with effects of relieving cough and reducing sputum and high-yield extraction method

A technology for relieving cough and reducing phlegm and an extraction method, which is applied in the field of biomedicine, can solve the problems of incapable of guaranteeing efficient and safe industrialized production, low extraction rate of active ingredients, large amount of solvent used, etc., and achieves a significant cough relieving effect, saves the use of solvents, The effect of high content of active ingredients

Pending Publication Date: 2022-05-10
GUANGDONG YUEWEI EDIBLE FUNGI TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the above-mentioned patents or documents, different extraction methods were used to investigate and optimize the extraction process of Huajuhong. There were large solid-liquid ratios, large solvent usage, and low extraction rates of active ingredients. The extraction rates of polysaccharides and flavonoids were not considered comprehensively. Organic Problems such as solvents cannot guarantee efficient and safe industrial production

Method used

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  • Exocarpium citri grandis extract with effects of relieving cough and reducing sputum and high-yield extraction method
  • Exocarpium citri grandis extract with effects of relieving cough and reducing sputum and high-yield extraction method
  • Exocarpium citri grandis extract with effects of relieving cough and reducing sputum and high-yield extraction method

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Experimental program
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Effect test

Embodiment 1

[0033] The present embodiment screens for extracting raw materials:

[0034] The contents of total flavonoids, crude polysaccharides and naringin in Huazhou Maojuhong, Guangxi Houroujuhong, Piaoxianghuajuhong and Guangjuhong were compared, and the results are shown in Table 1. According to the results in Table 1, it can be seen that the total flavonoids and crude polysaccharides of Huazhou Maojuhong are relatively high, so it is determined to choose Huazhou Maojuhong as the raw material.

[0035] Table 1 Contents of iconic components of orange-red cultivars from different origins

[0036]

Embodiment 2

[0038] This embodiment optimizes the process of extracting orange red water:

[0039] The main active ingredients of Huajuhong are polysaccharides and flavonoids. In the process of optimizing the process of the small test, combined with the actual needs of transformation and production, the sheet-shaped Huajuhong was used, and the ratio of solid to liquid, extraction times, and extraction time were set according to the results of single-factor experiments. level, use L 9 (3 4 ) table for an orthogonal experiment, and the investigation indicators are the extraction yield, polysaccharides, total flavonoids, and naringin content, and the results are shown in Tables 2-4.

[0040] Table 2 Huatangerine extraction process factor level table

[0041]

[0042] Table 3 The results of the orthogonal test of Huatangerine extraction and its visual analysis table

[0043]

[0044] Table 4 Results of variance analysis of comprehensive scores

[0045]

[0046] Note: F 0.05 (2,2)...

Embodiment 3

[0049] Weigh the decoction pieces of Huajuhong young fruit, add purified water, extract twice, the first time 14 times of water, extract at 100°C for 3 hours, the second time with 10 times of water, extract at 100°C for 3 hours, after the two extracts are centrifuged, pass through 200 mesh Filter the filter bag, combine the filtrates, concentrate at 50°C to 70°C to obtain the concentrated solution of Citrus Red extract, and spray the concentrated solution to dry the concentrated solution at a temperature of 150°C to 180°C and an outlet temperature of 65°C to 95°C to obtain Citrus Red Extract. The output rate of the obtained extract was 46.87%; the polysaccharide content was 21.40%, and the transfer rate was 99.1%; the total flavonoid content was 30.10%, and the transfer rate was 99.1%; the naringin content was 17.81%, and the transfer rate was 91.8%.

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Abstract

The invention belongs to the technical field of biological medicines, and discloses an exocarpium citri grandis extract with cough relieving and sputum reducing effects and a high-yield extraction method. The extraction method comprises the following steps: taking a young exocarpium citri grandis fruit raw material, adding 8-20 times of purified water, extracting for 1-4 times, extracting for 0.5-4 hours each time, centrifugally filtering, combining filtrates, and concentrating to obtain an exocarpium citri grandis extraction concentrated solution; and drying the obtained exocarpium citri grandis extract concentrated solution in one or more modes of hot air drying, spray drying, microwave drying and freeze drying to obtain the exocarpium citri grandis extract with the effects of relieving cough and reducing sputum. According to the extraction method, no organic solvent is used, no pungent smell exists, and environmental pollution is not caused; no special equipment is needed, and the industrial production safety is good. The extracted exocarpium citri grandis extract is clear in effective component content and high in extraction efficiency, and has a remarkable cough relieving effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a Huajuhong extract with the functions of relieving cough and reducing phlegm and a high-yield extraction method. Background technique [0002] Huajuhong, also known as Huazhoujuhong, is an authentic medicinal material in Guangdong Province. It is the immature or nearly mature dry outer peel of Citrus grandis Tomentosa or Citrus grandis (L.) Osbeck, a Rutaceae plant. Cold, dampness, Qi, expectorant effect. [0003] Huajuhong contains polysaccharides, flavonoids, coumarins, and volatile oils. Polysaccharide is one of the active ingredients of Huajuhong, which has anti-oxidation and anti-fatigue effects. Flavonoids are also one of the active ingredients of Huajuhong, which has good anti-inflammatory, cough and asthma effects. The flavonoids are mainly naringin, which accounts for more than 80% of the total flavonoids. It has the functions of relieving cough and r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P11/14A61P11/10A23L33/105A61K131/00
CPCA61K36/752A61P11/14A61P11/10A23L33/105A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2002/00A23V2200/314A23V2250/21
Inventor 焦春伟谢意珍随晶晶刘健文郑娇吉陈家明邓初夏
Owner GUANGDONG YUEWEI EDIBLE FUNGI TECH
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