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Rebamipide for preventing and treating celiac disease

A technology for rebamipide and celiac disease, applied in the field of rebamipide, can solve problems such as flattening of villi, destruction of the structure and function of the inner wall of the small intestinal mucosa, and hyperplasia of crypts

Pending Publication Date: 2022-04-12
方电力有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The above-mentioned inflammatory process leads to the destruction of the structure and function of the mucosal lining of the small intestine, resulting in flattening of villi and hyperplasia of crypts

Method used

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  • Rebamipide for preventing and treating celiac disease

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Embodiment Construction

[0045] Elimination-challenge test

[0046]To study the effect of rebamipide on celiac disease, a gluten challenge test was used. Adult patients entering the trial were stabilized on a gluten-free diet (GFD) that resulted in resolution of disease symptoms for at least 12 months. All participants were previously diagnosed with celiac disease by a physician using upper endoscopy and duodenal biopsy. Adherence to a gluten-free diet was demonstrated by a high villi height / crypt depth ratio (Vh / Cd > 2-3) and a decrease in anti-tTG antibody levels (less than 10 U / mL) after gluten was eliminated from the diet. ).

[0047] Patients were divided into two groups and received either rebamipide 100 mg three times daily or a placebo before each major meal. Both groups continued a gluten-free diet. Three months after the start of treatment (day 90) a gluten challenge test was performed. Patients consumed one slice of white bread containing approximately 2.7 g of wheat gluten per day for...

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Abstract

The present invention provides rebamipide for use in the prevention and / or treatment of celiac disease, in particular in humans with or at risk of increased intestinal permeability. Further, the present invention provides rebamipide for use in a method of inhibiting glutelin-induced increase in intestinal permeability.

Description

[0001] field of invention [0002] The present invention relates to rebamipide for use in the prophylaxis and / or treatment of celiac disease, especially in humans with or at risk of increased intestinal permeability. Further, the present invention relates to rebamipide for use in a method of inhibiting gluten-induced increase in intestinal permeability. Background technique [0003] Celiac disease (CD), also known as gluten-sensitive enteropathy, is a multifactorial autoimmune disorder that occurs in genetically predisposed individuals, especially those expressing the HLA-DQ2 / -DQ8 haplotype of those individuals. It is caused by an intolerance to gluten, a naturally occurring protein in wheat, rye, barley and related grains. If a person has celiac disease, eating gluten triggers autoimmune inflammation of the intestinal mucosa. Over time, this reaction destroys the villi, the small, finger-like protrusions in the lining of the small intestine that facilitate nutrient absorpt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4704A61P1/12A61P37/02C07D215/227
CPCA61K31/4704A61P1/00A61P1/04A61K45/06
Inventor 不公告发明人
Owner 方电力有限公司
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