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Analgesic uses of Pulsatillae or its extracts

A Pulsatilla saponin and drug technology, applied in the field of biomedicine, can solve the problems that there is no Pulsatilla saponin B5, etc.

Active Publication Date: 2022-06-17
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vast majority of researches reported in the previous reports focused on the many activities of Pulsatilla saponin B4. At present, there are few studies on the activity of Pulsatilla saponin B5. The application of infection drugs has proved that it has strong antiviral activity, but there is no report of Pulsatilla saponin B5 in analgesia

Method used

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  • Analgesic uses of Pulsatillae or its extracts
  • Analgesic uses of Pulsatillae or its extracts
  • Analgesic uses of Pulsatillae or its extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] 1. Experimental method

[0074] 1. Construction of SNL rat model

[0075] After the rats were anesthetized, the back skin was exposed by shaving. Cut the skin perpendicular to the line connecting the spine and the anterior superior iliac spine. The tissue was dissected by microscopy and the transverse process of the left L6 vertebral body was found, exposing the L4 and L5 spinal nerves. The L4 and L5 spinal nerves were separated and the L5 spinal nerve was ligated with surgical suture.

[0076] 2. Experimental drugs and reagents

[0077] 2% Sodium Pentobarbital; Pulsatilla Saponin B5; Pregabalin Capsules.

[0078] 3. Animal grouping and administration

[0079] Negative control group (Con), model group (SNL), Pulsatilla saponin B5 group (B5 for short), and pregabalin group (PGB).

[0080] There were 10 rats in each group. After modeling, the rats recovered for 3 days, and then were continuously administered for 14 days. Among them, B5 was intraperitoneally injected...

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Abstract

The present invention provides an application of Pulsatilla saponin B5 or its pharmaceutically acceptable salts, co-crystals, stereoisomers, prodrugs, solvates, and metabolites in the preparation of medicines for preventing and / or treating pain. Relieve the severity of neuropathic pain, such as improving the mechanical pain threshold caused by vertical stimulation of von Frey nylon filaments or the cold pain threshold caused by acetone stimulation in the spinal nerve ligation model, and the effect is better than that of pregabalin routinely used, and can It can reduce the economic burden of neuropathic pain patients and the society, and improve the quality of life of patients. It has great economic value and is recommended to be popularized and applied.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Pulsatilla saponin B5 in the preparation of analgesic medicines. Background technique [0002] Neuropathic pain has become the top killer of chronic pain due to its long course, poor efficacy, and serious impact on the quality of life of patients. Due to its high incidence and complex pathogenesis, there is still no effective treatment for the disease. Currently, drug treatment is the mainstay of treatment. Commonly used first-line analgesic drugs include tricyclic antidepressants (TCA), serotonin-nor Adrenaline reuptake inhibitors (SNRIs) and gabapentin, etc. The main effect of these drugs is not analgesia, but they are later found to have analgesic effects, so they are listed as adjuvant analgesics. Liver dysfunction, arrhythmia, mental illness and elderly patients have various side effects, such as dry mouth, sweating, excessive sleep and gastrointestin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/71A61P25/00A61K125/00
Inventor 郭秋岩赵明洪唐欢王继刚吕海宁马昂张迎夏斐史巧莉张珺哲
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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