Preparation method of self-assembled whitening active compound micelle and skin care product

A composite and self-assembly technology, applied in the field of skin care products, can solve the problems of large size, limited solubility, poor permeability of active ingredients, etc., and achieve the effects of preventing destruction of active ingredients, stable and orderly structure, and simple preparation method.

Pending Publication Date: 2022-04-12
深圳市瑞茵电子科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to the role of the skin barrier, the active ingredients have poor permeability and cannot exert their maximum effect. Currently, skin care products on the market usually use liposomes to encapsulate the active ingredients and deliver them to the bottom of the skin. However, due to the large size of ordinary liposomes, resulting in Its encapsulated active ingredients penetrate into the bottom of the skin at a slow rate, and the absorption effect is not good, and some insoluble lipophilic active ingredients are also limited by their solubility and cannot be well utilized
In addition, there are some products that use non-self-assembled micellar structures to encapsulate active ingredients, but this structure is not only not stable and orderly enough, but also the preparation process is cumbersome and complicated, and it is easy to introduce some unnecessary organic reagents, or affect the activity. Ingredient stability and structure causing damage

Method used

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  • Preparation method of self-assembled whitening active compound micelle and skin care product
  • Preparation method of self-assembled whitening active compound micelle and skin care product
  • Preparation method of self-assembled whitening active compound micelle and skin care product

Examples

Experimental program
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Effect test

preparation example Construction

[0030] Due to the role of the skin barrier, the active ingredients have poor permeability and cannot exert their maximum effect. Currently, skin care products on the market usually use liposomes to encapsulate the active ingredients and deliver them to the bottom of the skin. However, due to the large size of ordinary liposomes, resulting in Its encapsulated active ingredients penetrate into the bottom of the skin at a slow rate, and the absorption effect is not good, and some insoluble lipophilic active ingredients are also limited by their solubility and cannot be well utilized. In addition, there are some products that use non-self-assembled micellar structures to encapsulate active ingredients, but this structure is not only not stable and orderly enough, but also the preparation process is cumbersome and complicated, and it is easy to introduce some unnecessary organic reagents, or affect the activity. damage to the stability and structure of ingredients. In view of this,...

Embodiment 1

[0057] Table 1 Recipe table

[0058]

[0059] Weigh each raw material component according to Table 1 above.

[0060] Add water to the thickener, let it stand for 8 hours to swell, and obtain a thickener gel, which is set aside.

[0061] Dissolve water-soluble whitening ingredients in water, stir to dissolve completely, and form a water phase; add surfactant to the water phase, stir evenly, add active extract, stir at room temperature until completely dissolved, then add vitamin E powder, Stir well. Finally, drop the oily phase therein, stir at 700 rpm for 25 minutes, and then homogenize to make it self-assemble to form whitening active complex micelles.

[0062] Add the thickener gel prepared above into the whitening active compound micelles, stir and mix to obtain the whitening active compound micelles.

[0063] Tested by particle size analyzer, the test results are as follows: figure 1 As shown, the particle size is mainly distributed within 600±100nm.

Embodiment 2

[0065] Analogous to the preparation process of Example 1, the only difference between Example 2 and Example 1 is: the components of each raw material are shown in Table 2 below. The particle size is mainly distributed within 630±80nm by particle size analyzer.

[0066] Table 2 Formulation table

[0067]

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PUM

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Abstract

The invention discloses a preparation method of a self-assembled whitening active compound micelle and a skin care product, and the preparation method comprises the following steps: adding water into a thickening agent, and standing for swelling to obtain thickening agent gel; dissolving a water-soluble whitening component in water to form a water phase; adding the surfactant into the water phase, uniformly stirring, adding the active extract, uniformly stirring, adding the oil phase, and stirring, homogenizing and self-assembling to form the whitening active compound micelle; and adding a thickening agent gel into the whitening active compound micelle, and uniformly stirring and mixing to obtain the whitening active compound micelle product. The invention aims to prepare a whitening active compound micelle which can more quickly carry whitening components to permeate the bottom of the skin.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a preparation method of self-assembled whitening active compound micelles and a skin care product. Background technique [0002] Due to the role of the skin barrier, the active ingredients have poor permeability and cannot exert their maximum effect. Currently, skin care products on the market usually use liposomes to encapsulate the active ingredients and deliver them to the bottom of the skin. However, due to the large size of ordinary liposomes, resulting in Its encapsulated active ingredients penetrate into the bottom of the skin at a slow rate, and the absorption effect is not good, and some insoluble lipophilic active ingredients are also limited by their solubility and cannot be well utilized. In addition, there are some products that use non-self-assembled micellar structures to encapsulate active ingredients, but this structure is not only not stable and order...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/9794A61K8/9789A61K8/67A61K8/64A61K8/368A61K8/02A61Q19/02
Inventor 王寅
Owner 深圳市瑞茵电子科技有限公司
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