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Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing

A technology of gallium ion and water injection, which is used in pharmaceutical formulations, medical science, bandages, etc., to achieve the effects of good tissue adhesion, good biocompatibility, and not easy to fall off

Pending Publication Date: 2022-03-18
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gallium ions have not been used in the development of antibacterial hydrogel dressings so far.

Method used

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  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing
  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing
  • Injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as preparation method and application of injectable hydrogel dressing

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Effect test

Embodiment 1

[0040] This embodiment provides a preparation method of an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the following steps:

[0041] (1) Dissolve 480mg chitosan in 8mL deionized water to obtain S1 solution;

[0042] (2) Dissolve 200mg of tannic acid in 2mL of deionized water to obtain S2 solution;

[0043] (3) Dissolve 30 mg of gallium nitrate in 300 μL of deionized water to obtain S3 solution;

[0044] (4) Mix 8mL of S1 solution, 2mL of S2 solution and 300μL of S3 solution, stir at 25°C for 1min to make it evenly mixed, then adjust the pH value of the mixed solution to 7.5 with 0.1 mol / L sodium hydroxide solution, and let it stand for 5min The mixed solution is fully gelled to obtain the injectable hydrogel dressing based on polyphenol-gallium ion coordination (chitosan / tannic acid / gallium nitrate hydrogel dressing).

Embodiment 2

[0046] This embodiment provides a preparation method of an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the following steps:

[0047] (1) Dissolve 500 mg of sulfonated chitosan (sulfonated chitosan was prepared by referring to the method provided in the literature Biomaterials, 2009, 30, 1715–1724) in 8 mL of deionized water to obtain S1 solution;

[0048] (2) Dissolve 100mg of anthocyanins in 2mL of deionized water to obtain S2 solution;

[0049] (3) Dissolve 50 mg of gallium nitrate in 300 μL of deionized water to obtain S3 solution;

[0050] (4) Mix 8mL of S1 solution, 2mL of S2 solution and 300μL of S3 solution, stir at 25°C for 1min to make it evenly mixed, then adjust the pH value of the mixed solution to 7.5 with 0.1mol / L sodium bicarbonate solution, and let stand for 5min The mixed solution is fully gelled to obtain the injectable hydrogel dressing based on polyphenol-gallium ion coordination (sulfonated ...

Embodiment 3

[0052] This embodiment provides a preparation method of an injectable hydrogel dressing based on polyphenol-gallium ion coordination, the preparation method comprising the following steps:

[0053] (1) Dissolve 600mg chitosan in 9mL deionized water to obtain S1 solution;

[0054] (2) Dissolve 75mg of epigallocatechin gallate (EGCG) in 1.5mL of deionized water to obtain S2 solution;

[0055] (3) Dissolve 60 mg of gallium chloride in 300 μL of deionized water to obtain S3 solution;

[0056] (4) Mix 9mL of S1 solution, 1.5mL of S2 solution and 300μL of S3 solution, stir at 25°C for 1min to mix well, then adjust the pH value of the mixed solution to 8.0 with 0.1mol / L sodium carbonate solution, and let it stand for 10 min to fully gel the mixed solution to obtain the injectable hydrogel dressing based on polyphenol-gallium ion coordination (chitosan / EGCG / gallium chloride hydrogel dressing).

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Abstract

The invention particularly relates to an injectable hydrogel dressing based on polyphenol-gallium ion coordination as well as a preparation method and application of the injectable hydrogel dressing. The hydrogel compound dressing is prepared from the following raw materials in percentage by mass: 3-30% of an antibacterial high-molecular compound, 3-30% of a natural polyphenol compound, 3-30% of an inorganic gallium compound and deionized water. The hydrogel auxiliary material has good injectable performance, antibacterial performance, hemostatic performance and antioxidant effect, and can significantly improve the wound healing effect in a mouse full-thickness skin wound simulation model.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an injectable hydrogel dressing based on polyphenol-gallium ion coordination and its preparation method and application. Background technique [0002] When the skin is traumatized, it will be infected by various bacteria, which can cause complications and even death in severe cases. Therefore, it is very important to treat wounds, accelerate wound healing, and prevent various bacterial infections. Using dressings to treat wounds can effectively prevent the above problems from happening. A good dressing needs to have the advantages of low price, convenient use, excellent air permeability, strong moisture retention, and good heat retention, and has the functions of debridement, absorption of exudate, and prevention of secondary infection. [0003] Hydrogel is a kind of polymer with hydrophilicity and three-dimensional network structure, which is favored by the...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L5/08C08L5/02C08K5/134C08K5/13C08K3/28C08K3/16C08K3/30C08K5/098
CPCC08J3/075C08J3/24A61L26/008A61L26/0004A61L26/0023A61L26/0066C08J2305/08C08J2305/02C08K5/134C08K5/13C08K3/28C08K3/16C08K2003/3045C08K5/098A61L2400/06A61L2300/404A61L2300/418A61L2300/236A61L2300/102C08L5/08C08L5/02
Inventor 黄达王明达翁祖铨杜佳豪
Owner FUZHOU UNIVERSITY
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