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Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof

A soluble, micro-needle sticker technology, applied in micro-needle, antibacterial, antifungal and other directions, can solve the problems of needle body retention, single component, easy needle breakage, etc., to reduce dosage, improve mechanical properties, reduce The effect of drug resistance

Pending Publication Date: 2022-03-15
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid microneedles are made of metal or non-degradable polymers. The disadvantage is that the needles are prone to breakage, and there are certain safety hazards when the needles stay in the skin.
The problem with coated microneedles is that the drug on the coating surface reduces the sharpness of the microneedle tip, increases the friction between the needle body and the skin, and easily leads to incomplete insertion of the microneedle
Invention patent CN109010257A discloses the preparation of a multilayer soluble microneedle array. Although the method used is a double-layer microneedle preparation method, the composition is single, and both the base and the backing contain hyaluronic acid, which reduces the need for microneedles. The functionality, in essence, still belongs to the integrated microneedle preparation method
However, a large number of polycationic and polyanionic polysaccharides will undergo rapid electrostatic adsorption when mixed, resulting in coagulation or gelation, making the preparation of microneedles impossible.

Method used

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  • Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof
  • Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof

Examples

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preparation example Construction

[0021] Such as figure 1 As shown, the preparation method of the antibacterial and healing-promoting soluble microneedle patch in the present invention comprises the following steps:

[0022] (1) The configuration of the precursor solution for promoting healing and moisturizing: add sodium alginate into deionized water at 70~80°C, stir well until it is completely dissolved, after the temperature of the solution drops to 40°C, add hyaluronic acid, and stir well until the solution is dissolved Clarified to obtain the healing and moisturizing precursor A;

[0023] (2) Configuration of antibacterial and anti-inflammatory layer solution: add polyvinyl alcohol to deionized water at 90~95°C, stir until it dissolves into a uniform solution, and when the temperature of the solution drops to 50~60°C, add chitosan quaternary ammonium in turn Salt, polyhexamethylene guanidine hydrochloride and gelatin are fully stirred until the solution is evenly mixed to obtain antibacterial and anti-in...

Embodiment 1

[0027] A preparation method for layer-by-layer deposition of an antibacterial and healing-promoting soluble microneedle patch, the method comprising the following steps:

[0028] (1) Configuration of the healing and moisturizing precursor solution: Add 2 parts of sodium alginate into deionized water at 70~80°C, stir until it is completely dissolved. After the temperature of the solution drops to 40°C, add 5 parts of hyaluronic acid, fully Stir until the solution is clear to obtain the healing and moisturizing precursor A;

[0029] (2) Configuration of the antibacterial and anti-inflammatory layer solution: add 6 parts of polyvinyl alcohol to deionized water at 90~95°C, stir until it dissolves into a uniform solution, and when the temperature of the solution drops to 50~60°C, add 5 parts of shell polysaccharide quaternary ammonium salt, 2 parts of polyhexamethyleneguanidine hydrochloride and 1 part of gelatin, fully stirred until the solution is evenly mixed to obtain antibacte...

Embodiment 2

[0033] (1) Configuration of the healing and moisturizing precursor solution: Add 2 parts of sodium alginate into deionized water at 70~80°C, stir well until it is completely dissolved. After the temperature of the solution drops to 40°C, add 6 parts of hyaluronic acid, fully Stir until the solution is clear to obtain the healing and moisturizing precursor A;

[0034] (2) Configuration of the antibacterial and anti-inflammatory layer solution: add 4 parts of polyvinyl alcohol to deionized water at 90~95°C, stir until it dissolves into a uniform solution, and when the temperature of the solution drops to 50~60°C, add 6 parts of shell polysaccharide quaternary ammonium salt, 3 parts of polyhexamethyleneguanidine hydrochloride and 1 part of gelatin, fully stirred until the solution is evenly mixed to obtain antibacterial and anti-inflammatory precursor solution B;

[0035](3) Preparation of layer-by-layer deposition of antibacterial and healing-promoting soluble microneedles: extr...

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Abstract

The invention discloses a preparation method of a layer-by-layer deposition antibacterial healing-promoting soluble microneedle patch, a microneedle belongs to the field of microneedle preparation methods, and the adopted preparation method is a layer-by-layer deposition micro-molding method. The preparation method has the advantage that materials which cannot be used together due to chemical reaction caused by blending can be used together. According to the antibacterial and healing-promoting soluble microneedle patch, the healing-promoting moisturizing layer is used as a needle tip, the antibacterial and anti-inflammatory layer is deposited on the needle tip, finally, the healing-promoting moisturizing layer is deposited, a functional layer is prepared, and a TPU medical adhesive tape is used as a backing layer. Wherein the healing promoting and moisturizing layer contains the following components: hyaluronic acid and sodium alginate. The antibacterial and anti-inflammatory layer comprises the following components: chitosan quaternary ammonium salt, gelatin, polyhexamethylene guanidine hydrochloride and polyvinyl alcohol. According to the invention, the excellent healing-promoting and moisturizing effects of polyanion polysaccharide and the excellent antibacterial and anti-inflammatory properties of polycation are deposited layer by layer, so that the healing-promoting, moisturizing, antibacterial and anti-inflammatory effects are synchronously carried out.

Description

technical field [0001] The invention belongs to the field of microneedle preparation methods, and in particular relates to a preparation method for layer-by-layer deposition of antibacterial and healing-promoting soluble microneedle patches. Background technique [0002] Microneedle is a new type of transdermal drug delivery technology, which consists of micron-scale fine needle tips arranged on the backing in an array, which can just pass through the stratum corneum of the skin without touching the pain nerve, and forms a drug delivery system on the skin surface. Channels allow drugs or natural antibacterial substances to reach the specified depth of the skin and enter the subcutaneous capillary network to be absorbed, which promotes the penetration of drugs and natural antibacterial substances without causing pain and destructive damage to the skin. Therefore, microneedles help to improve the drug absorption and the patient's compliance with natural antibacterial substance...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/00A61K31/785A61K47/32A61K47/42A61P17/00A61P31/04A61P31/10A61K31/722A61K31/728A61K31/734
CPCA61M37/0015A61K9/0021A61K31/785A61K31/722A61K31/728A61K31/734A61K47/32A61K47/42A61P31/04A61P31/10A61P17/00A61M2037/0053A61M2037/0046A61K2300/00
Inventor 高光辉陈颖
Owner CHANGCHUN UNIV OF TECH
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