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Application of sildenafil citrate/tadalafil/vardenafil in preparation of medicine for treating myopia

A technology of sildenafil citrate and tadalafil, which is applied in drug combinations, pharmaceutical formulas, active ingredients of heterocyclic compounds, etc., can solve problems such as the lack of data and the inability to judge whether eye drops are effective in preventing myopia , to achieve the effect of reducing the axial length, delaying the development of myopia, and reducing the degree of myopia

Pending Publication Date: 2022-03-15
JINAN SANWEI MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main active ingredient used in the above-mentioned eye drops is homatropine, but there is no corresponding data to support whether homatropine can effectively treat myopia
Therefore, without any data support, it is impossible to judge whether the eye drops are effective in preventing myopia

Method used

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  • Application of sildenafil citrate/tadalafil/vardenafil in preparation of medicine for treating myopia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Sildenafil citrate is applied in the preparation of myopia medicine, and specific method is as follows:

[0028] Dissolve sildenafil citrate in normal saline, keep its concentration at about 0.7 mg / mL, add eye drops auxiliary materials, mix well; then drop the above eye drops in the eyes, 1 to 3 drops each time, 1 to 4 times a day.

[0029] Eye drops accessories are: sodium hyaluronate 0.1%, sodium hydroxymethylcellulose 0.05%, sodium carboxymethylcellulose 0.02%, glycerin 0.02%, polylysine 0.01%.

Embodiment 2

[0031] Tadalafil is used in the preparation of myopia medicine, and the specific method is as follows:

[0032] Dissolve sildenafil citrate in normal saline, keep the concentration at about 0.8 mg / mL, add eye drops auxiliary materials, mix well; then drop the above eye drops in the eyes, 1 to 3 drops each time, 1 to 4 times a day.

[0033] Eye drops accessories are: sodium hyaluronate 0.1%, sodium hydroxymethylcellulose 0.02%, sodium carboxymethylcellulose 0.03%, glycerin 0.03%, polylysine 0.02%.

Embodiment 3

[0035] Vardenafil is used in the preparation of myopia medicine, and the specific method is as follows:

[0036] Dissolve sildenafil citrate in normal saline, keep its concentration at about 0.6 mg / mL, add eye drops auxiliary materials, mix well; then drop the above eye drops in the eyes, 1 to 3 drops each time, 1 to 4 times a day.

[0037] Eye drops accessories are: sodium hyaluronate 0.1%, sodium hydroxymethylcellulose 0.03%, sodium carboxymethylcellulose 0.02%, glycerin 0.04%, polylysine 0.01%.

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Abstract

The invention belongs to the technical field of new application of medicines, and particularly relates to application of sildenafil citrate / tadalafil / vardenafil in preparation of medicines for treating myopia. The application of sildenafil citrate, tadalafil and vardenafil in preparation of the medicine for treating myopia is the key protection content of the invention, and the medicine disclosed by the invention is a liquid medicine, such as eye drops. The medicine containing sildenafil, tadalafil and vardenafil for treating shortsightedness is also the key protection content of the invention. The medicine further comprises conventional auxiliary materials contained in the eye drops, such as preservatives, excipients and the like. The medicine sildenafil citrate, tadalafil and vardenafil provided by the invention have the beneficial effects that the medicine sildenafil citrate, tadalafil and vardenafil provided by the invention are applied to the treatment of myopia medicines, so that the blood supply of retina or choroid or ciliary muscle or sclera is effectively improved; or the axial length of the inner wall of the eyeball is reduced, or the adjusting force of eyes is enhanced, so that the purpose of treating myopia is achieved.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of sildenafil citrate / tadalafil / vardenafil in the preparation of medicines for treating myopia. Background technique [0002] So far, there is no ideal delay and treatment for myopia, and the degree of myopia can only be removed through invasive operations such as laser myopia surgery after adulthood. The incidence of myopia is getting higher and higher, which has become a serious social problem. Finding a non-invasive and effective method to delay myopia and even treat myopia has great social and economic significance. [0003] CN105998020A discloses an eye drop capable of preventing myopia, including homatropine, preservative, pH regulator, isotonic regulator and diluent, and the ratio of each component is: homatropine: 0.01%-0.3% ; Preservative: 0.001%-0.05%; pH regulator: adjust the pH value to 6.6-7.2; Isotonic regulator 1%-10%; Dil...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/4985A61K31/53A61P27/10A61P9/10
CPCA61K31/519A61K31/4985A61K31/53A61P27/10A61P9/10
Inventor 李志伟牟国营
Owner JINAN SANWEI MEDICAL INSTR CO LTD
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