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Application of microneedle patch in regulation and control of scar tissue mechanical microenvironment

A microneedle patch and mechanical microtechnology, applied in the direction of microneedles, needles, drug combinations, etc., can solve the problems of invasive small treatment methods, and achieve the effects of improved self-management, convenient use, and good biocompatibility

Pending Publication Date: 2022-03-04
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, a less invasive, convenient and effective modality remains unsolved in the mechanotherapy of hypertrophic scars

Method used

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  • Application of microneedle patch in regulation and control of scar tissue mechanical microenvironment
  • Application of microneedle patch in regulation and control of scar tissue mechanical microenvironment
  • Application of microneedle patch in regulation and control of scar tissue mechanical microenvironment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation process of embodiment 1 microneedle patch

[0015] Microneedle structure design: the array density is 15×15 needles / cm 2 ), the needle body is a square pyramid, the side length of the bottom of the cone is 300µm, and the height of the needle body is 1mm;

[0016] Preparation of microneedle male mold: using high-strength resin as the base material, 3D printing is used to prepare microneedle male molds with different array densities;

[0017] Preparation of the microneedle negative mold: Clean the 3D printed positive mold with deionized water, pour PDMS (polydimethylsiloxane) and curing agent (mass ratio 10:1, w / w) on the positive mold, Cured at 80°C for 2 hours, and demolded to obtain a microneedle negative mold.

[0018] Preparation of microneedle patches.

[0019] Mold pretreatment: Clean the surface of the PDMS negative mold with deionized water and isopropanol in sequence and dry it;

[0020] Polymer solution perfusion: silk fibroin solution (10%,...

Embodiment 2

[0023] Example 2 microneedle sticking treatment of rabbit ear hypertrophic scar

[0024] (1) Treatment methods:

[0025] Disease model: rabbit ear hypertrophic scar;

[0026] Treatment process: first wipe and disinfect the scar with iodine, then press and puncture the sterilized microneedle patch of three different materials into the scar tissue, fix it with tape, and keep it for 7-30 days;

[0027] Grouping: control group (scars without microneedle treatment), microneedle treatment group (SF, PLA, PLGA).

[0028] (2) Treatment effect:

[0029] After 1 month of treatment, the scar appearance improved significantly. figure 1 As shown, after the microneedle intervention, the L value (L: lightness, the larger the L value indicates whiter) and the A value (A: redness, the larger the A value indicates redder) of the skin at the scar tissue site was detected by the colorimeter. The normal skin was gradually approached, while the untreated scar was significantly different from th...

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Abstract

The invention relates to a scar improvement technology, in particular to application of a microneedle patch to regulation and control of a scar tissue mechanical microenvironment. The technical problem to be solved by the invention is to provide a new choice for improving scars. Research finds that the microneedle patch can regulate and control the microenvironment of fibrotic tissues, and a foundation is laid for subsequent further preparation of medical supplies for effectively improving hypertrophic scars.

Description

technical field [0001] The invention relates to scar improvement technology, in particular to the use of microneedle sticking in regulating the mechanical microenvironment of fibrotic tissue. Background technique [0002] Hypertrophic scar (HS) is the result of pathological changes in which damaged tissue undergoes fibrosis during the repair process. The abnormal increase and excessive deposition of extracellular matrix (mainly collagen and fibronectin) in the scar group not only increase the tissue hardness, but also increase the mechanical stress in the extracellular matrix and the stress field intensity derived from it, which leads to fibroblast Mechanical stimulation is activated to induce the up-regulation of transforming growth factor (TGF-β1), α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF), and the secretion of type I collagen and fibronectin, which further promotes Pathological changes of fibrosis. Conversely, release or reduction of mechanic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61P17/02A61M37/00
CPCA61K9/7023A61K9/0021A61K47/42A61P17/02A61M37/0015A61M2037/0061
Inventor 张庆罗高兴谭江琳
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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