Soluble hair-growing microneedle and preparation method thereof

A soluble, micro-needle technology, applied in the field of biomedicine, to achieve the effect of preventing hair loss, promoting regrowth, and shortening the hair growth cycle

Pending Publication Date: 2022-03-01
YANTAI MAGIC NANOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor effect and long time of the existing hair growth methods, the present invention provides a soluble hair growth microneedle, which selects the medicinal ingredients for improving or treating hair loss, gray hair, dryness and other skin problems, and then through the overall preparation process Design, load the drug ingredients into the microneedle, when the microneedle penetrates the skin, the microneedle body quickly dissolves in the skin interstitial fluid, releases the drug ingredient at the same time, efficiently delivers the drug and exerts its efficacy

Method used

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  • Soluble hair-growing microneedle and preparation method thereof
  • Soluble hair-growing microneedle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of microneedle body fluid

[0034] Dissolve 0.2g of polyvinylpyrrolidone and 1.3g of sodium hyaluronate in 10g of deionized water, stir magnetically until fully dissolved, then weigh 0.15g of palmitoyl hexapeptide-25, 0.05g of acetyl tetrapeptide-3, and 0.1g of three Peptide-2, 0.1g tripeptide-32, 0.1g oligopeptide-1, 0.05g palmitoyl tetrapeptide-10, 0.01g stem cell exosomes, 0.05g arborvitae extract, 0.01g hinokitiol, 0.05g Polygonum multiflorum extract 0.01g β-carotene, 0.01g ginger extract, 0.001g azelaic acid, stir evenly, filter with a 0.22μm aqueous syringe filter to remove excess air bubbles, and obtain the microneedle body fluid.

Embodiment 2

[0037] Example 2 Preparation of Microneedle Base Liquid

[0038] Dissolve 0.5g of polyvinylpyrrolidone, 0.3g of polyvinyl alcohol, 0.6g of sodium hyaluronate, and 0.1g of glycerin in 100g of deionized water, stir until fully dissolved, and filter with a 0.22μm aqueous syringe filter to remove excess air bubbles, namely Obtain microneedle base fluid.

Embodiment 3

[0039] The preparation of embodiment 3 microneedle

[0040] Pour the microneedle body fluids of Example 1 and Comparative Example 1 into two microneedle female molds respectively, and then put the microneedle female molds in a vacuum drying oven at a temperature of 25°C and a vacuum degree of -0.1Mpa After sufficient vacuum injection molding, remove the excess microneedle body liquid on the surface; slowly pour the microneedle base liquid, place the microneedle negative mold in a blast drying oven to fully dry for 24 hours, and demould, respectively to obtain hair growth microneedles and comparative examples Microneedles.

[0041] in, figure 1 It is a scanning electron microscope picture of a hair growth microneedle, the soluble hair growth microneedle includes a microneedle body 1 and a microneedle base 2, and the microneedle body 1 includes excipient materials and hair growth active ingredients 3; figure 2 It is a schematic diagram of the structure of the hair growth micr...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to a soluble hair growth microneedle and a preparation method thereof. The hair growth micro-needle comprises a micro-needle body and a micro-needle base, the micro-needle body comprises a shaping material and a hair-growing effective component, and the mass percentage ratio of the shaping material to the hair-growing effective component is (60-90%): (10-40%); the hair-growing effective components comprise hair-growing polypeptides, repairing polypeptides, plant extracts and antibacterial oil-control components. The preparation method comprises the following steps: preparing the microneedle body liquid, preparing the microneedle substrate liquid and preparing the microneedle. According to the soluble hair growth micro-needle, medicine components for improving or treating skin problems such as alopecia, white hair and dryness are selected, then the medicine components are loaded into the micro-needle through the design of an overall preparation technology, after the micro-needle pierces into the skin, the micro-needle body is rapidly dissolved in skin tissue fluid, meanwhile, the medicine components are released, and the effect of promoting hair growth is achieved. The medicine is efficiently delivered and the medicine effect is exerted.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a soluble hair growth microneedle and a preparation method thereof. Background technique [0002] With the aggravation of environmental pollution and the acceleration of the pace of life, people's life pressure increases, excessive brain use, short sleep time, and poor sleep quality lead to dry hair, split ends, hair loss, excessive dandruff, and gray hair. , especially the use of alkaline shampoo, perm and hair dye all further affect the normal cell metabolism and scalp microenvironment of the scalp, leading to increasingly prominent hair problems. [0003] At present, for problems such as hair loss and excessive dandruff, external drugs are mainly used for smearing or washing, which can only temporarily improve the symptoms. After stopping the use, the problem will reappear soon and cannot be cured. In addition, in order to improve hair loss and improve persona...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K9/00A61K47/10A61P17/14A61M37/00A61K38/07A61K38/06A61K38/02A61K31/122A61K31/015A61K36/9068A61K31/20
CPCA61K38/08A61K38/07A61K38/06A61K38/02A61K36/14A61K31/122A61K36/704A61K31/015A61K36/9068A61K31/20A61K9/0021A61K47/10A61K47/36A61P17/14A61M37/0015A61M2037/0053A61K2300/00
Inventor 史强
Owner YANTAI MAGIC NANOTECHNOLOGY CO LTD
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