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Albendazole and ivermectin premix as well as preparation method and application thereof

A technology of albendazole ivermectin and albendazole, which is applied in the field of albendazole ivermectin premix and its preparation, can solve the problems of boar dead sperm, high toxicity of albendazole, Unsatisfactory effect of parasites and other problems, to achieve the effect of uniform mixing and good dispersion

Pending Publication Date: 2022-03-01
江西博莱兽药科技协同创新有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The use of conventional doses can kill the parasites in the pig body, but the parasites on the pig body surface are basically ineffective. Large, sow abortion and stillbirth, boar dead sperm, fattening pig poisoning and other toxic side effects

Method used

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  • Albendazole and ivermectin premix as well as preparation method and application thereof
  • Albendazole and ivermectin premix as well as preparation method and application thereof
  • Albendazole and ivermectin premix as well as preparation method and application thereof

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preparation example Construction

[0028] In addition, the present invention provides a preparation method of albendazole ivermectin premix, which comprises heating and melting the components, emulsifying and stirring into a drug suspension, and spray-drying the drug suspension to condense into a spherical shape particles.

[0029] Specifically, first heat glycerol monostearate to 85-95°C, stir until it melts, then add polyethylene glycol, keep it at 85-95°C for 8-12 minutes after melting, then add activated carbon, Insulate and stir at ℃ for 8-12 minutes; then add albendazole and ivermectin, stir evenly to obtain a drug suspension, divide the drug suspension into 4-5 times for homogenization, each time for 8- After 12 minutes, stop for 3-5 minutes, and homogenize for a total of 40-60 minutes to obtain a homogeneous liquid. Adjust the temperature of the homogeneous liquid to 70-80 ° C, and then spray dry the homogeneous liquid to granulate. The rotational speed during spray drying is 16000-20000rpm, after the ...

Embodiment 1

[0036]The present embodiment provides a kind of albendazole ivermectin premix, its component comprises by mass percentage: albendazole 6.3%, ivermectin 0.29%, activated carbon 5%, polyethylene glycol 58.41%, glyceryl monostearate 30%.

[0037] Its preparation method comprises: based on 1kg, accurately weighed glyceryl monostearate according to the above mass percentage, heating to 90°C, stirring until melting, and then slowly adding precisely weighed polyethylene glycol to the melted monostearin Stir while adding to fatty acid glyceride until it melts into a liquid, keep warm at 90°C for 10 minutes, add the amount of activated carbon used in the process, keep warm at 90°C and stir at 1000rpm for 10 minutes. Add the amount of albendazole and ivermectin used in the process, start stirring, and after the materials are stirred until there is no obvious accumulation, start the homogenizer, and homogenize the suspension solution in 4 times (stop 3-5 minutes after starting for 10 min...

Embodiment 2

[0039] The present embodiment provides a kind of albendazole ivermectin premix, its component comprises by mass percent: albendazole 6.5%, ivermectin 0.3%, activated carbon 5.5%, polyethylene glycol 57.7%, glyceryl monostearate 30%.

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Abstract

The invention discloses an albendazole and ivermectin premix as well as a preparation method and application thereof, and relates to the technical field of veterinary drugs. The albendazole and ivermectin premixing agent is prepared from the following components in percentage by mass: 5.5 to 6.5 percent of albendazole, 0.2 to 0.3 percent of ivermectin, 4 to 6 percent of activated carbon, 55 to 65 percent of polyethylene glycol and 25 to 35 percent of glyceryl monostearate. The preparation method comprises the following steps: heating, melting, emulsifying and stirring the components to form a medicine suspension, and carrying out spray drying and condensation on the medicine suspension to form spherical particles. According to the albendazole and ivermectin premixing agent provided by the invention, the dosage of albendazole and ivermectin is controlled, specific auxiliary materials are selected, albendazole and ivermectin are dispersed in molten liquid of the auxiliary materials, and spherical fine particles are formed through spray drying and condensation, so that the albendazole and ivermectin premixing agent is prepared. The albendazole and ivermectin premixing agent prepared by the invention can be uniformly mixed and is good in dispersity.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to an albendazole ivermectin premix and a preparation method and application thereof. Background technique [0002] The main components of albendazole ivermectin premix are albendazole and ivermectin, which is an antiparasitic drug. Albendazole has broad-spectrum anthelmintic activity, and has a strong killing effect on nematodes, tapeworms, and trematodes. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms. Ivermectin has a good repelling effect on internal and external parasites, especially arthropod insects and internal nematodes, and is mainly used to expel gastrointestinal nematodes, lung nematodes and external parasites in pigs. Its deworming mechanism is to promote the release of γ-...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/16A61K47/04A61K47/10A61K47/14A61P33/14A61K31/4184
CPCA61K31/4184A61K31/7048A61K9/1641A61K9/1617A61K9/1611A61P33/14A61K2300/00
Inventor 姜恒胡国彬唐进波熊俊芳肖欣戈
Owner 江西博莱兽药科技协同创新有限公司
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