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Ion mobility separation system with rotating field confinement

A technology of ion mobility and ions, which is applied in separation tube vacuum systems, particle separation tubes, ion sources/guns, etc., can solve the problems of the ability to prevent ion loss and limit the overall performance of the TIMS system, etc.

Pending Publication Date: 2022-02-22
BRUKER DALTONIK GMBH & CO KG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these radial confinement systems are limited in their ability to prevent ion loss, which in turn limits the overall performance of the TIMS system

Method used

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  • Ion mobility separation system with rotating field confinement
  • Ion mobility separation system with rotating field confinement
  • Ion mobility separation system with rotating field confinement

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Embodiment Construction

[0074] Figure 1A-Figure 1C Three stages of operation of a general form of a trapped ion mobility separator 100 according to the invention are schematically shown. The trapped ion mobility separator 100 includes an ion channel 101 that generally includes a structure surrounding the ion path and includes electrodes for generating an electric field within the ion channel 101 . Such as Figure 1A As shown in , ions 102 enter from one side of the channel 101 and will eventually travel to the other side of the channel, where they are temporarily trapped along the way at mobility-dependent locations. Ions 102 are molecular constituents of the sample material of interest that have been ionized and introduced into ion channels, typically from a known type of ionization source such as electrospray or MALDI (matrix assisted laser desorption ionization) type ion source or CI (chemical ionization )source of ion. Ions 102 enter channel 101 with arbitrary position and velocity, but will b...

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Abstract

An ion mobility separator includes an ion path with a central axis along which ions travel, the ion path containing a gas. A first force is applied to the ions in a first axial direction, and a second force that varies spatially along the ion path is applied to the ions in second axial direction opposite the first axial direction. A rotating confinement field has a radially-inhomogeneous electric potential with relative maxima and minima that rotate about the central axis as a function of time, the confinement field exerting a radial confinement force on the ions in a radial direction toward the central axis. The ion mobility separator may be operated at elevated pressures including ambient pressure and higher. The first and / or second axial forces may be a constant or gradient gas flow, a constant or gradient electric field or an axial component of the rotating confinement field.

Description

technical field [0001] The present invention relates generally to the field of ion mobility spectrometry, and more specifically, to trapped ion mobility spectrometry (TIMS) and hybrid systems coupling ion mobility spectrometry and mass spectrometry. Background technique [0002] Ion mobility spectrometry (IMS) is an analytical technique used to study the mobility of ions in a buffer gas and to separate them according to their mobility. An inherent feature of ion mobility spectrometry is that the mobility of ions in a buffer gas depends on the molecular geometry of the ions, making it often possible to resolve and thus separate isomers or conformers that cannot be resolved by mass spectrometry. Many applications also utilize the ability to determine an analyte ion cross-section from its measured mobility. Cross-sectional knowledge has proven to be important in many fields, including identifying compound classes and detailing structures, especially in the field of structural ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/00H01J49/06G01N27/623G01N27/622
CPCH01J49/0027H01J49/0031H01J49/004H01J49/063G01N27/622G01N27/62G01N27/623H01J49/00H01J49/06H01J49/065H01J49/10H01J49/24H01J49/4215
Inventor 阿尼什·普拉巴卡兰
Owner BRUKER DALTONIK GMBH & CO KG
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