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Konjac glucomannan targeted delivery capsule and preparation method thereof

A konjac glucomannan, targeting technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problem of low drug loading, achieve the effects of improving the release amount, the preparation method is convenient and fast, and avoiding damage

Active Publication Date: 2022-02-18
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a konjac glucomannan targeted delivery capsule and its preparation method, which is used to solve the problem of konjac glucomannan as a targeted delivery carrier in the prior art. The problem of low drug loading

Method used

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  • Konjac glucomannan targeted delivery capsule and preparation method thereof
  • Konjac glucomannan targeted delivery capsule and preparation method thereof
  • Konjac glucomannan targeted delivery capsule and preparation method thereof

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preparation example Construction

[0031] The invention provides a method for preparing konjac glucomannan targeted delivery capsules, comprising the following steps:

[0032] S1. Preparation of DKGM powder: Mix KGM powder with an ethanol solution with a volume concentration of 25-50%, stir and react at 20-70°C for 5-10min, add lye, and continue to stir and react at 20-70°C for 10-10min After 20 minutes, the DKGM crude product was obtained; the DKGM crude product was washed and dried to obtain DKGM powder;

[0033] S2. Preparation of DKGM / active ingredient microcapsules: Dissolve the water-soluble active ingredient in pure water to obtain an active ingredient solution, add the DKGM powder in step S1 to the active ingredient solution, stir for more than 15 minutes, centrifuge, and take the precipitate, DKGM / active ingredient microcapsules were obtained after vacuum freeze-drying.

[0034] In step S1, alkali lye is sodium hydroxide solution, and the ratio of the quality of KGM powder and the molar number of alka...

Embodiment 1

[0046] A konjac glucomannan targeted delivery capsule, the preparation method of which comprises the following steps:

[0047] S1. Preparation of DKGM powder: Put 3.0 g of KGM powder into a beaker with stirring, add 100 mL of ethanol solution with a volume concentration of 30% into the beaker, put the beaker into a microwave reactor, turn on the microwave reactor, and control the reaction temperature 50°C, stirred for 5 minutes, and the stirring speed was 150rpm. Then, 10 mL of NaOH solution with a concentration of 0.2 mol / mL was added to the beaker, the reaction temperature was controlled at 50 ° C under microwave heating conditions, and the reaction was continued to stir for 10 min at a stirring speed of 150 rpm to obtain crude DKGM. After the reaction, the DKGM crude product is gradiently washed with ethanol solutions with a volume concentration of 30%, 60% and 90%, respectively, so as to wash away excess alkali, and then dehydrated with absolute ethanol to obtain a DKGM se...

Embodiment 2～ Embodiment 6

[0050] The differences between Embodiment 2 to Embodiment 6 and Embodiment 1 are shown in Table 1.

[0051] Table 1 The process parameter table of each embodiment

[0052]

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Abstract

The invention belongs to the technical field of biological materials and slow release, and particularly discloses a konjac glucomannan targeted delivery capsule and a preparation method thereof. The preparation method comprises the following steps: 1) preparation of DKGM powder: specifically, subjecting KGM powder to deacetylation with alkali liquor, and then carrying out washing and drying so as to obtain the DKGM powder; and 2) preparation of a DKGM / active ingredient microcapsule: dissolving a water-soluble active ingredient into pure water, adding the DKGM powder obtained in the step 1), carrying out stirring and centrifuging, taking a precipitate, and carrying out washing and drying to obtain the DKGM / active ingredient microcapsule. The DKGM / active ingredient microcapsule disclosed by the invention can be applied to preparation of a colon targeted drug; and the drug loading capacity of the active ingredient in the konjac glucomannan targeted delivery capsule is improved, and the drug release capacity of the konjac glucomannan targeted delivery capsule at the colon part is improved.

Description

technical field [0001] The invention relates to the technical field of biological materials and sustained release, in particular to a konjac glucomannan targeted delivery capsule and a preparation method thereof. Background technique [0002] Colon diseases (such as colitis, colon cancer, etc.) role in colon cancer. For example, Proanthocyanidins (PACs) are a common class of polyphenols, and their strong antioxidant properties make them have great potential in the prevention of colonic diseases. Studies have reported that metabolites with anti-inflammatory activity (such as short-chain fatty acids, especially propionic acid) increase in the colon of animals after eating foods rich in PACs, and PACs can also inhibit the proliferation of colon cancer cells and promote its apoptosis. However, due to the shortcomings of these antioxidant active ingredients such as easy decomposition and poor stability when exposed to light, their application has been challenged. The encapsul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36
CPCA61K9/5036Y02A50/30
Inventor 刘雄覃小丽王朦朦
Owner SOUTHWEST UNIVERSITY
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