Application of darunavir in preparation of medicine for treating pulmonary fibrosis diseases

A technology for pulmonary fibrosis and darunavir, which is applied in the field of biomedicine, can solve the problems of pulmonary fibrosis without darunavir, and achieves alleviation or improvement of pulmonary fibrosis diseases, good application prospects, and alleviation of pulmonary fibrosis. Effect

Pending Publication Date: 2022-02-11
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no report that darunavir can slow down pulmonary fibrosis

Method used

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  • Application of darunavir in preparation of medicine for treating pulmonary fibrosis diseases
  • Application of darunavir in preparation of medicine for treating pulmonary fibrosis diseases
  • Application of darunavir in preparation of medicine for treating pulmonary fibrosis diseases

Examples

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Effect test

Embodiment 1

[0029] The effect of darunavir on bleomycin-induced pulmonary fibrosis in mice

[0030] 1. Preparation of pulmonary fibrosis animal model: male C57BL / 6J, wild-type mice (8-10 weeks old), give mice intraperitoneal injection anesthesia with mass volume concentration 10% chloral hydrate by 0.5ml / 100g (body weight) After anesthetizing the mouse, weigh and record, fix the mouse on the operating table, disinfect the neck with 70% alcohol, cut a 1 cm long wound vertically in the neck of the mouse with a scalpel, and use micro forceps to separate the tissue to expose the trachea. Insert the syringe into the trachea through the gap between the cartilage rings of the trachea towards the end of the heart, then slowly inject 2 U / kg of bleomycin physiological saline solution in a volume appropriate to its body weight, and immediately turn the animal upright and rotate left and right to make the liquid in the lungs evenly distributed within.

[0031] 2. Grouping

[0032] Blank control gro...

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Abstract

The invention discloses application of darunavir in preparation of the medicine for treating the pulmonary fibrosis diseases, darunavir has a good effect on pulmonary fibrosis, has no adverse reaction, can slow down bleomycin-induced pulmonary fibrosis of mice, provides a new medicine for treating, relieving or improving the pulmonary fibrosis diseases, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a new application of darunavir, in particular to the application of darunavir in the preparation of medicines for treating pulmonary fibrosis. Background technique [0002] With the intensification of environmental pollution, air quality continues to decline, smog weather increases, and the incidence of lung diseases continues to increase. Pulmonary fibrosis (PF) is the end-stage clinical manifestation of many pulmonary interstitial diseases with different etiologies, characterized by persistent alveolar damage, fibroblast proliferation, and massive extracellular matrix (ECM) deposition. A disease that causes alveolar and interstitial inflammation and fibrosis to varying degrees, leading to structural destruction of the lung and respiratory failure, so it is also called interstitial lung disease (ILD) or diffuse parenchymal lung disease (diffuse parenchymal lung disease, DPLD)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61P11/00
CPCA61K31/635A61P11/00
Inventor 杨诚毕谆周红刚李霄鹤
Owner NANKAI UNIV
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