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Application of tectoridin in preparation of medicine for treating autoimmune diseases and serious inflammatory diseases

An irisin and drug technology, applied in the field of medicine, can solve the problem of no direct connection between T cells and mitochondrial uncoupling proteins, and achieve the effect of broadening the selection field

Pending Publication Date: 2022-02-08
THE SECOND HOSPITAL OF SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the research on irisin on fat is relatively sufficient at present, but because the immune system disorder disease is mainly related to the performance of T cells, but T cells are not directly related to mitochondrial uncoupling protein 1 (UCP-1), so there is currently no No study of irisin to treat autoimmune disease

Method used

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  • Application of tectoridin in preparation of medicine for treating autoimmune diseases and serious inflammatory diseases
  • Application of tectoridin in preparation of medicine for treating autoimmune diseases and serious inflammatory diseases
  • Application of tectoridin in preparation of medicine for treating autoimmune diseases and serious inflammatory diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0026] 1. Preparation of irisin

[0027] It can be obtained by yeast expression and purification, and existing methods can be used, such as the document Irisin Stimulates Browning of White Adipocytes through Mitogen-Activated Protein Kinase p38 MAPKinase and ERK MAP Kinase Signaling.Diabetes.Diabetes 2014Feb; 63(2):514-25 records that Iris The preparation process of the element.

[0028] 2. Screening and culturing of primary human CD3+ T cells

[0029] (1) Human peripheral blood mononuclear cells (PBMC) were separated by Ficoll density gradient centrifugation, washed 3 times with phosphate buffer (pH7.2), and the cells were reselected;

[0030] (2) Add CD3+ T cell positive sorting magnetic beads to the reselected cells in step (1) according to the ratio in the instructions, mix well and incubate at 4°C for half an hour;

[0031] (3) Place the sorting column on the sorting rack, and pass 1ml of phosphate buffer solution through the column to equilibrate twice;

[0032] (4) A...

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Abstract

The invention discloses application of tectoridin in preparation of a medicine for treating autoimmune diseases and serious inflammatory diseases, and relates to the technical field of medicines.The tectoridin can promote differentiation of CD3 + T cells to Treg cells and is used for preparing the medicine for promoting differentiation of the CD3 + T cells to the Treg cells. The invention provides application of tectoridin in preparation of a medicine for treating autoimmune diseases. The result shows that the tectoridin mediates the immune regulation effect; a new possible intervention target is provided for preparing and treating autoimmune diseases; the tectoridin can be applied to research and development of autoimmune disease protein drugs, and a brand new choice and thought are provided for research and development of drugs for treating autoimmune diseases; and the selection field of drugs for treating autoimmune diseases is widened.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of irisin in the preparation of medicines for treating autoimmune diseases and severe inflammatory diseases. Background technique [0002] Autoimmune disease (autoimmune disease, AID) is a combination of various internal and external factors, the body's own immune tolerance is destroyed, the immune system has an overly strong or long-lasting immune response to self-antigens, resulting in the body's own cells and tissues A type of disease in which case damage or dysfunction occurs and corresponding clinical symptoms appear. Although autoimmune diseases are relatively uncommon, their morbidity and mortality are relatively high. The incidence of AID in the world is 7-10%, and it is increasing year by year. However, there is currently no definite treatment for AID disease, because the progression of the disease is gradual, so severe tissue damage may have occurred b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P37/02A61P29/00A61P19/02A61P3/10A61P25/00A61P15/00A61P21/04
CPCA61K38/39A61P37/02A61P29/00A61P19/02A61P3/10A61P25/00A61P15/00A61P21/04
Inventor 郑成云唐东起李慧孔德晓
Owner THE SECOND HOSPITAL OF SHANDONG UNIV
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