Tumor targeted diagnosis and treatment integrated nanoparticle and application thereof

Abstract

The invention relates to a tumor targeted diagnosis and treatment integrated nanoparticle and application thereof, the tumor targeted diagnosis and treatment integrated nanoparticle comprises: (i) a nanoparticle core, the nano-particle core comprises manganese dioxide modified nano-gold particles and an anti-tumor drug; (ii) a liposome shell comprising an AIE imaging molecule and for encapsulating the nanoparticle core; and (iii) a targeting molecule attached to the liposome shell. The nanoparticle has a bimodal imaging function, and can effectively overcome the influence of a tumor hypoxia microenvironment on chemotherapy, photodynamic therapy and photothermal therapy; the drug can be released on demand at a tumor part, cancer cell death can be induced, the liver tumor treatment effect can be improved, bimodal imaging can be provided, and accurate and efficient tumor treatment can be achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to nanoparticles integrated with tumor targeting diagnosis and treatment and applications thereof. Background technique [0002] Malignant tumors are one of the important diseases that threaten human health. The morbidity and mortality have been high and continue to increase. At present, the clinical treatment methods for liver cancer mainly include surgical resection, ablation therapy, hepatic arterial chemoembolization, radiotherapy, chemotherapy and gene therapy. Among them, surgical resection can obtain a longer survival period, and surgical resection is generally the first choice for patients who meet the indications for surgery. For inoperable patients, interventional embolization, radiofrequency ablation, chemotherapy, radiotherapy, and targeted drugs such as bevacizumab can be used. Many treatment plans will use a combination of multiple treatment methods according t...

AI Technical Summary

Problems solved by technology

However, these multifunctional nano-drug delivery systems are usually limited by the following factors, resulting in unsatisfactory imaging and therapeutic effects: 1. Drug resistance caused by the complex microenvironment of the tumor; 2. The surface charge of the nano-platform is immutable, resulting in its It is easy to remove in the blood circulation, and the uptake of tumor cells is reduced; 3. Lack of precise and controllable drug release methods, it is impossible to achieve effective drug release on demand in lesions

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