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Application of recombinant human-derived III type collagen in preparation of superficial wound repair material

A collagen and superficial technology, applied in the field of bioengineering, can solve the problems of poor quick effect and poor effect, and achieve the effect of improving the overall size and depth of the wound surface, shortening the wound healing time, and improving the quality of wound healing.

Pending Publication Date: 2022-01-11
JIANGSU JLAND BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are some scar-removing collagen materials on the market for repairing superficial wounds, but the effect is not good in terms of quick and marked effects

Method used

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  • Application of recombinant human-derived III type collagen in preparation of superficial wound repair material
  • Application of recombinant human-derived III type collagen in preparation of superficial wound repair material
  • Application of recombinant human-derived III type collagen in preparation of superficial wound repair material

Examples

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Effect test

Embodiment 2

[0065] Select 120 volunteers, aged 15-45 years, with scars within one year, and randomly divide them into 3 groups, 40 people in each group, to ensure that the effective number is 30 people. Cameras were used to take pictures, and Antera3D skin tester (Ireland) was used to analyze the total size and depth of superficial wounds, and the texture of the skin.

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Abstract

The invention discloses an application of recombinant human collagen III type in preparation of a superficial wound repair material. The recombinant human III type collagen contains 498 amino acids, the theoretical molecular weight is about 54.5 kd, and the constructed recombinant human III type collagen expression strain can effectively, stably and massively express the recombinant human III type collagen. The recombinant human collagen has good hydrophilicity and stability, the structure of the recombinant human collagen is 100% the same as that of a corresponding part of a natural collagen gene sequence, and immunological rejection is not caused when the recombinant human collagen is applied to a human body. When the recombinant human III type collagen is used as a superficial wound repair material, the scabbing time is advanced by 1-2 days, the wound healing time is obviously shortened, the wound is smooth and smooth, the wound healing quality is improved, no obvious scar exists, and the recombinant human III type collagen is suitable for the fields of skin care products, medical instruments and the like.

Description

technical field [0001] The invention belongs to the technical field of bioengineering and relates to the application of recombinant human type III collagen in the preparation of superficial wound repair materials. Background technique [0002] Collagen, as the most abundant protein in the extracellular matrix, the most important structural protein in connective tissue and almost all parenchyma interstitial tissues, plays a role in stabilizing tissues and organs and maintaining their structural integrity. It is used in biomedical materials , Skin care products and other fields are widely used. The currently used collagen is mainly natural collagen, which is not easily soluble in water, and is derived from cattle, pigs, fish and other animals. Its molecular weight is different, its properties are complex, and further processing is difficult. application. In recent years, good progress has been made in solving these problems by using gene construction technology and expressin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P17/02A61L15/32A61L15/44A61K8/65A61Q19/00C12N15/81C12N15/12C12R1/84
CPCA61K38/39A61P17/02A61L15/325A61L15/44A61K8/65A61Q19/00C12N15/815C07K14/78A61L2300/252A61L2300/412
Inventor 赵健烽徐鹏程余继刚高力虎冯丽萍黄建民
Owner JIANGSU JLAND BIOTECH CO LTD
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