Application of hydrogen and hydrogenated coral calcium in preparation of medicines for treating hyperpyrexia and mental disorder caused by methylamphetamine

A technology for methamphetamine and mental disorders, which is applied in the field of antipsychotic drugs, can solve problems such as obstacles to drug withdrawal and the difficulty of METH withdrawal, and achieve the effect of expanding application value and alleviating hippocampal neuroplastic damage

Pending Publication Date: 2022-01-11
HEBEI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned neuropsychiatric symptoms are one of the key obstacles to drug withdrawal, making METH withdrawal more difficult

Method used

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  • Application of hydrogen and hydrogenated coral calcium in preparation of medicines for treating hyperpyrexia and mental disorder caused by methylamphetamine
  • Application of hydrogen and hydrogenated coral calcium in preparation of medicines for treating hyperpyrexia and mental disorder caused by methylamphetamine
  • Application of hydrogen and hydrogenated coral calcium in preparation of medicines for treating hyperpyrexia and mental disorder caused by methylamphetamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This example provides the application effect of CCH in hyperthermia induced by METH.

[0031] 1. Experimental method

[0032] The male C57BL / 6 mice were divided into 4 groups, respectively: ①Normal saline control group (6); ②METH group (10); ③METH+CCH 100mg / kg pretreatment group (12); ④METH+CCH 200mg / kg pretreatment group (11).

[0033] The feeding environment of the mice in each group was 22±1°C, RH60%±5%, and the light cycle was 7:00-19:00 light and 19:00-7:00 dark.

[0034] Considering that long-term intragastric administration may cause stress to the animals, and then affect the behavior, so in this experiment, only CCH was administered by intragastric administration for 7 days.

[0035] The dosing regimens for each group were as follows:

[0036] ①Normal saline control group: At room temperature of 28±1°C, intraperitoneally inject normal saline at a dosage of 10 mg / kg, 4 times a day (1 injection every 6 hours), for a total of 3 days.

[0037] ②METH group: At r...

Embodiment 2

[0044] This example provides the application effect of CCH in mental disorders caused by METH.

[0045] 1. Experimental method

[0046] The male C57BL / 6 mice were divided into 4 groups, respectively: ①Normal saline control group (12); ②METH group (8); ③METH+CCH 100mg / kg treatment group (10); ④METH+CCH200mg / kg Treatment group (10 rats).

[0047] The feeding environment of the mice in each group was 22±1°C, RH60%±5%, and the light cycle was 7:00-19:00 light and 19:00-7:00 dark.

[0048] The dosing regimens for each group were as follows:

[0049] ①Normal saline control group: At room temperature of 28±1°C, intraperitoneally inject normal saline at a dosage of 10 mg / kg, 4 times a day (1 injection every 6 hours), for a total of 3 days.

[0050] ②METH group: At room temperature of 28±1°C, methamphetamine was injected intraperitoneally at a dose of 10 mg / kg, 4 times a day (1 injection every 6 hours), for a total of 3 days.

[0051] ③ METH+CCH 100mg / kg treatment group: intraperit...

Embodiment 3

[0063] This example provides the application effect of CCH on hippocampal synaptic plastic injury caused by METH.

[0064] 1. Experimental method

[0065] The male C57BL / 6 mice were divided into 4 groups, respectively: ①Normal saline control group (3); ②METH group (3); ③METH+CCH 100mg / kg treatment group (3); ④METH+CCH 200mg / kg kg treatment group (3 rats).

[0066] The feeding environment of the mice in each group was 22±1°C, RH60%±5%, and the light cycle was 7:00-19:00 light and 19:00-7:00 dark.

[0067] The dosing regimens for each group were as follows:

[0068] ①Normal saline control group: At room temperature of 28±1°C, intraperitoneally inject normal saline at a dosage of 10 mg / kg, 4 times a day (1 injection every 6 hours), for a total of 3 days.

[0069] ②METH group: At room temperature of 28±1°C, methamphetamine was injected intraperitoneally at a dose of 10 mg / kg, 4 times a day (1 injection every 6 hours), for a total of 3 days.

[0070] ③ METH+CCH 100mg / kg treatme...

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PUM

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Abstract

The invention relates to the technical field of anti-mental disorder medicines, in particular to application of hydrogen and hydrogenated coral calcium in preparation of medicines for treating hyperpyrexia and mental disorder caused by METHs (Methamphetamine). Experimental research shows that hydrogen can relieve hyperpyrexia and depression-like behaviors caused by METH and effectively relieve the depression state in the METH withdrawal process, so that METH withdrawal can be facilitated. Hydrogenated coral calcium can continuously generate hydrogen in a body, after administration, the hydrogen concentration in the body can reach a high level, the hydrogen can be continuously released in the body, serious hyperpyrexia caused by exposure of METH can be remarkably reduced, depression-like behaviors can be inhibited, and damage of METH to mouse hippocampus synaptic plasticity is remarkably improved.

Description

technical field [0001] The invention relates to the technical field of antipsychotic drugs, in particular to the application of hydrogen and coral calcium hydrochloride in the preparation of drugs for treating high fever and mental disorders caused by methamphetamine. Background technique [0002] Methamphetamine (Methamphetamine, METH) is currently the most widely abused new drug in my country. Frequent use can lead to abnormal behavior and cognitive ability. Neuropsychiatric symptoms such as schizophrenia and neurodegenerative diseases have caused great harm to personal health and social public safety. There are many commonalities between the withdrawal symptoms of amphetamine-type stimulants and the behavior of depressed people, and anxiety or depression-like behaviors appear in animal models of chronic or subacute METH exposure, and the depression state will last during the withdrawal of METH exist. In addition, stimulating factors in the external environment that promo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K35/614A61P29/00A61P25/24
CPCA61K33/00A61K35/614A61K9/0053A61P29/00A61P25/24
Inventor 文迪马春玲王鑫涛佟博男
Owner HEBEI MEDICAL UNIVERSITY
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