High-brightness nanodot fluorophores by covalent functionalization

A nano-dot and functional group technology, applied in the field of high-brightness nano-dot fluorophores through covalent functionalization, can solve problems such as low brightness and low photostability

Pending Publication Date: 2022-01-04
MICHIGAN TECHNOLOGICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, reliable tracking and quantification of fluorophores is challenging due to the low brightness and low photostability of commercial fluorophores

Method used

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  • High-brightness nanodot fluorophores by covalent functionalization
  • High-brightness nanodot fluorophores by covalent functionalization
  • High-brightness nanodot fluorophores by covalent functionalization

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Embodiment Construction

[0018] Very commonly, high brightness fluorophores comprise a carrier element, a fluorescent element, and a linker connecting the carrier element to the fluorescent element. For biomedical applications, each of the carrier element, linker, and fluorescent element must be biocompatible (although the requirements for biocompatibility will vary with the specific application).

[0019] An example carrier element is a processed nanomaterial such as carbon nanotubes (CNTs) and boron nitride nanotubes (BNNTs), both of which are useful in biomedical applications such as cellular drug delivery and spectroscopy applications. However, fluorescent elements attached to carbon nanotubes have been shown to exhibit quenching or reduction in fluorescence brightness.

[0020] It has been found that certain fluorophores with nanomaterial supports not only exhibit no quenching effect, but also exhibit orders of magnitude brighter brightness than other known fluorophores, as will be discussed in t...

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Abstract

A example compound according to the present disclosure includes, among other possible things, a nanodot carrier, a moiety, and a linker having first and second functional groups, wherein the first functional group is covalently linked to the nanodot carrier, and the second functional group is covalently linked to the moiety. An example method of making a nanodot carrier is also disclosed.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 855,121, filed May 31, 2019, which is hereby incorporated in its entirety. This application is a continuation-in-part of U.S. Patent Application Serial No. 15 / 953,200, filed April 13, 2018, which claims priority to U.S. Provisional Patent Application Serial No. 62 / 485,379, filed April 13, 2017, both Both are hereby incorporated herein in their entirety. [0003] Statement Regarding Federally Sponsored Research [0004] The invention described herein was made with government support under Grant #1261910, Grant #1521057 and Grant #1738466 awarded by the National Science Foundation. The government has certain rights in this invention. Background technique [0005] Fluorophores are chemical compounds with fluorescent properties that have biomedical applications. For example, fluorophores can be used as tracers or dyes for the specific s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64C09K11/06C09K11/02
CPCG01N21/6428G01N21/6486C09K11/025C09K11/06C09K2211/1088A61B5/0071A61B5/0075G01N33/533G01N33/543
Inventor 叶玉牵惠奇
Owner MICHIGAN TECHNOLOGICAL UNIVERSITY
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