Application of whey protein as broad-spectrum inhibitor of coronaviruses

A whey protein, coronavirus technology, applied in disease applications, whey protein field

Pending Publication Date: 2021-12-31
PEKING UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although recent research reports have shown that a variety of candidate vaccines have shown good safety and efficacy in animal experiments and phase I clinical trials, and a series of drug molecule candidates have a certain ability to inhibit viruses, but there is still a long way to go. It is necessary to increase the screening and research of drugs to find drugs with better curative effect and better safety

Method used

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  • Application of whey protein as broad-spectrum inhibitor of coronaviruses
  • Application of whey protein as broad-spectrum inhibitor of coronaviruses
  • Application of whey protein as broad-spectrum inhibitor of coronaviruses

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0027] Experimental Example: Effect of Whey Protein on Inhibiting Coronavirus Infection

[0028] Detection principle: xCoV is highly homologous to SARS-CoV-2. Through the comparison and analysis of the whole genome and each viral coding gene (nucleotide level and amino acid level), it is found that: xCoV is highly homologous to SARS-CoV-2, and is highly homologous to SARS-CoV The homology of the S protein of -2 reaches 92.5%, which is the virus with the highest homology to the S protein of SARS-CoV-2 that has been successfully isolated and cultured so far, whether it is the whole genome level or the key gene S gene for virus adsorption into cells , the homology of xCoV and SARS-CoV-2 is much higher than that of SARS virus, such as figure 1 shown.

[0029] The inventors used an alternative model of SARS-CoV-2, the xCoV virus model, to avoid the risk and cumbersomeness of P3 laboratory experiments. The xCoV virus can be cultivated in ordinary P2 laboratories, and can be used a...

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Abstract

The invention provides novel application of whey protein and degraded products thereof. The whey protein and the degraded products thereof can be used for preventing and / or treating diseases caused by coronaviruses such as serious acute respiratory syndrome coronavirus (SARS-CoV), novel coronavirus (SARS-CoV-2) and similar novel coronaviruses such as pangolin coronavirus (xCoV) as broad-spectrum inhibitors of the coronaviruses. The whey protein can be used for inhibiting adhesion, entry and replication of viruses, is an effective multi-target inhibitor and is high in safety, so that the whey protein can be applied to prevention and / or treatment of the diseases caused by the coronaviruses.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of whey protein for preventing and / or treating diseases caused by coronaviruses. Background technique [0002] The 2019 novel coronavirus (2019-nCoV or SARS-CoV-2, which causes novel coronavirus pneumonia COVID-19) is currently the seventh known coronavirus that can infect humans, and the remaining six are HCoV-229E, HCoV- OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV and MERS-CoV. Among them, HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 are less pathogenic and generally cause respiratory symptoms, similar to the common cold or pneumonia. The other three are highly pathogenic and infectious, and the diseases they cause include severe acute respiratory syndrome (SARS, 2002-2004), Middle East respiratory syndrome (MERS, 2012-present) and new coronavirus disease (COVID-19). Therefore, how to block the spread of coronavirus, prevent infection and develop new effective d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/38A61K38/17A61P31/14
CPCA61K38/38A61K38/1709A61P31/14
Inventor 向宽辉范华昊周乙华庄辉童贻刚李彤骆予倩宋立华安小平王立钦胡运甲金香淑洪碧霞
Owner PEKING UNIV
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