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Manganese dioxide-poly(3,4-ethylenedioxythiophene) biocoating with osteogenic activity and its preparation method and application

A bio-coating and bone-promoting technology, applied in the biomedical field, can solve the problems of difficulty in large-scale preparation and high cost, and achieve the effects of good electrochemical activity, low cost and simple operation.

Active Publication Date: 2022-08-09
江苏先进无机材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional methods such as electrochemical deposition need to prepare conductive polymer layers in organic solvents, which are relatively expensive, difficult to prepare on a large scale, and have certain biological safety risks.

Method used

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  • Manganese dioxide-poly(3,4-ethylenedioxythiophene) biocoating with osteogenic activity and its preparation method and application
  • Manganese dioxide-poly(3,4-ethylenedioxythiophene) biocoating with osteogenic activity and its preparation method and application
  • Manganese dioxide-poly(3,4-ethylenedioxythiophene) biocoating with osteogenic activity and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] A: MnO 2 - Preparation of PEDOT composite coating

[0041] The titanium sheet polished with sandpaper was placed in a mixed solution of potassium permanganate, potassium chloride and hydrochloric acid, and MnO was grown in situ on the surface of the titanium sheet by a hydrothermal reaction method. 2 Coating (denoted as M0); MnO 2 The coated titanium flakes were placed in a sulfuric acid solution containing EDOT monomer, and were prepared in MnO by in-situ polymerization. 2 Preparation of PEDOT coating on the surface to obtain MnO 2 -PEDOT composite coating.

[0042] Wherein the volume of the ionic mixture used in the hydrothermal reaction method is 60mL, the concentration of potassium permanganate used is 0.001mol / L, the concentration of potassium chloride is 0.003mol / L, and the concentration of hydrochloric acid is 0.004mol / L. The hydrothermal reaction time was 12 h, and the hydrothermal reaction temperature was 120 °C, respectively.

[0043] Wherein the used sul...

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Abstract

The invention discloses a manganese dioxide-poly(3,4-ethylenedioxythiophene) biological coating with osteopromoting activity and a preparation method and application thereof. The MnO 2 ‑PEDOT biocoating is achieved by in situ growth of MnO on the substrate surface 2 layer and in MnO 2 MnO with nanosheet structure and connected pore structure obtained by in situ polymerization of layer surface to generate PEDOT 2 ‑PEDOT biocoating.

Description

technical field [0001] The invention relates to a biological coating with good osteogenic activity and a preparation method and application thereof, in particular to a manganese dioxide-poly(3,4-ethylenedioxide with excellent electrochemical activity and excellent osteogenic activity) thiophene) (MnO 2 -PEDOT) composite coating, its preparation method and its application in bone tissue repair and replacement materials, belonging to the field of biomedical technology. Background technique [0002] Titanium metal and its alloys have good biocompatibility and are widely used clinically as substitute materials for bone repair. However, due to its biological inertness, it is difficult for titanium to form a firm bond with bone tissue, which affects its long-term stability after implantation. Surface modification methods of traditional orthopaedic implant materials, such as constructing appropriate nanostructures, can improve the surface activity of implant materials and promote...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/06A61L27/04A61L27/50A61L27/54
CPCA61L27/306A61L27/34A61L27/06A61L27/045A61L27/50A61L27/54A61L2300/412A61L2430/02A61L2400/18A61L2420/02A61L2400/12A61L2420/04A61L2420/08C08L65/00
Inventor 李恺刘诗伟邵丹丹谢有桃郑学斌
Owner 江苏先进无机材料研究院
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