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Manganese dioxide-poly (3, 4-ethylenedioxythiophene) biological coating with osteogenesis promoting activity as well as preparation method and application thereof

A bio-coating and bone-promoting technology, applied in the biomedical field, can solve the problems of high cost and difficulty in large-scale preparation, and achieve low cost, good electrochemical activity, and the effect of promoting repair

Active Publication Date: 2021-12-24
江苏先进无机材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional methods such as electrochemical deposition need to prepare conductive polymer layers in organic solvents, which are relatively expensive, difficult to prepare on a large scale, and have certain biological safety risks.

Method used

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  • Manganese dioxide-poly (3, 4-ethylenedioxythiophene) biological coating with osteogenesis promoting activity as well as preparation method and application thereof
  • Manganese dioxide-poly (3, 4-ethylenedioxythiophene) biological coating with osteogenesis promoting activity as well as preparation method and application thereof
  • Manganese dioxide-poly (3, 4-ethylenedioxythiophene) biological coating with osteogenesis promoting activity as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment

[0040] A: MnO 2 - Preparation of PEDOT composite coating

[0041] Sandpaper-polished titanium sheets were placed in a mixed solution of potassium permanganate, potassium chloride and hydrochloric acid, and MnO was grown in situ on the surface of titanium sheets by hydrothermal reaction method 2 Coating (denoted as M0); the MnO 2 The coated titanium sheet was placed in a sulfuric acid solution containing EDOT monomer, and the MnO 2 Prepare PEDOT coating on the surface to get MnO 2 - PEDOT composite coating.

[0042] Among them, the volume of the ion mixed liquid used in the hydrothermal reaction method is 60 mL, the concentration of potassium permanganate used is 0.001 mol / L, the concentration of potassium chloride is 0.003 mol / L, and the concentration of hydrochloric acid is 0.004 mol / L. The hydrothermal reaction time is 12 hours, and the hydrothermal reaction temperatures are 120° C. respectively.

[0043] The sulfuric acid concentration used in the in-situ polymerizatio...

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Abstract

The invention discloses a manganese dioxide-poly (3, 4-ethylenedioxythiophene) biological coating with osteogenesis promoting activity as well as a preparation method and application thereof. The MnO2-PEDOT biological coating is a MnO2-PEDOT biological coating with a nanosheet structure and a communicating pore structure, and is obtained by growing a MnO2 layer on the surface of a base material in situ and polymerizing PEDOT on the surface of the MnO2 layer in situ.

Description

technical field [0001] The present invention relates to a biological coating with good osteogenic activity and its preparation method and application, in particular to a manganese dioxide-poly(3,4-ethylenedioxide) with excellent electrochemical activity and osteogenic activity Thiophene) (MnO 2 -PEDOT) composite coating and its preparation method as well as its application in bone tissue repair and replacement materials, belonging to the field of biomedical technology. Background technique [0002] Titanium and its alloys have good biocompatibility, and are widely used as bone repair substitute materials clinically. However, due to its biological inertia, it is difficult for titanium to form a firm bond with bone tissue, which affects its long-term stability after implantation. The surface modification methods of traditional orthopedic implant materials, such as constructing suitable nanostructures, can improve the surface activity of implant materials and promote the rapi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/34A61L27/06A61L27/04A61L27/50A61L27/54
CPCA61L27/306A61L27/34A61L27/06A61L27/045A61L27/50A61L27/54A61L2300/412A61L2430/02A61L2400/18A61L2420/02A61L2400/12A61L2420/04A61L2420/08C08L65/00
Inventor 李恺刘诗伟邵丹丹谢有桃郑学斌
Owner 江苏先进无机材料研究院
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