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Polypeptide composition for promoting skin microcirculation and application of polypeptide composition

A technology of polypeptide composition and skin microcirculation, which is applied in the field of skin microcirculation promoter and polypeptide composition to promote skin microcirculation, which can solve the problem that the main components of natural extracts are not clear, and the skin microcirculation and skin irritation are not really achieved. Accumulation and other issues

Pending Publication Date: 2021-12-07
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The compositions that are used to promote skin microcirculation generally have the following problems: (1) adopt cool and refreshing skin feeling regulators such as menthol lactate, menthol, borneol, etc. to make the skin have instant numbness and cool feeling, and achieve a (2) Using natural extracts such as horse chestnut seed extract and safflower extract to achieve the effect of promoting skin blood circulation
Even if there is a step of volatilization to remove solvent in the extraction process, there will be solvent residue in the extracted product
Because the main components of natural extracts are not clear, the content of active substances is low, the effective addition amount is large, and there are problems with solvent residues, it is easy to cause the cosmetics to cause cumulative irritation to human skin during use, and even cause skin allergies in severe cases. question

Method used

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  • Polypeptide composition for promoting skin microcirculation and application of polypeptide composition
  • Polypeptide composition for promoting skin microcirculation and application of polypeptide composition
  • Polypeptide composition for promoting skin microcirculation and application of polypeptide composition

Examples

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Effect test

Embodiment 1

[0026] A polypeptide composition for promoting skin microcirculation, which consists of carnosine and palmitoyl pentapeptide-4. Applying the polypeptide composition on the skin surface can promote skin microcirculation, ensure skin nutrition supply, and relieve skin discomfort symptoms.

[0027] Carnosine (alanylhistidine, Carnosine) is a dipeptide composed of β-alanine and histidine. Carnosine has strong antioxidant capacity, and it can stably protect cell membranes, especially as a water-soluble A free radical scavenger that prevents cell membrane peroxidation. Compared with other biological antioxidants such as VE and VC in the past, carnosine has a stronger antioxidant capacity, which can delay skin aging caused by free radicals. In addition, carnosine also helps the repair of skin tissue, and has therapeutic and preventive effects on skin allergies caused by ultraviolet rays.

[0028] Palmitoyl pentapeptide refers to a pentapeptide composed of five amino acids in sequen...

Embodiment 2

[0035] A skin microcirculation-promoting polypeptide composition whose composition is as in Example 1, the mass ratio of carnosine and palmitoyl pentapeptide-4 is 1:4. Among them, carnosine can be selected from China Rongzhen Biology (article number RZ-19032609, content ≥ 99%) or German Symrise ( content ≥ 99.5%), palmitoyl pentapeptide-4 can be selected from China Xi'an Luoshen Biology (article number LS289, content ≥ 98%) or China Meihe Biotechnology (article number MH-041401, content ≥ 99%). Those skilled in the art can select relevant commercially available products according to actual needs, and this embodiment will not give examples one by one. The carnosine of the present embodiment selects German virtue's Xin (Symrise) ( Content ≥ 99.5%), Palmitoyl Pentapeptide-4 is selected from China Meihe Biology (article number MH-041401, content ≥ 99%).

Embodiment 3

[0037] A kind of polypeptide composition that promotes skin microcirculation as embodiment 1, the mass ratio of carnosine and palmitoyl pentapeptide-4 is 3:7. The source of carnosine and palmitoyl pentapeptide-4 of the present embodiment is identical with embodiment 2.

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Abstract

The invention provides a polypeptide composition for promoting skin microcirculation and an application of the polypeptide composition. The polypeptide composition consists of carnosine and palmitoyl pentapeptide-4, wherein the mass ratio of the carnosine to the palmitoyl pentapeptide-4 is (1: 4)-(4: 1). The effective dose range of the polypeptide composition disclosed by the invention is 10 [mu] g / mL to 2000 [mu] g / mL. Compared with a cool skin feeling regulator, the polypeptide composition can increase the content of acetylcholine in skin or inhibit the activity of thrombin in skin microvessels, and the effect of promoting skin microcirculation is really achieved. Compared with natural extracts, the polypeptide composition is clear in composition and free of redundant impurities, avoids the situation that the natural extracts are complex in composition and hidden skin allergens exist or solvent, heavy metals and other impurity residues are introduced due to an industrial extraction process, and greatly reduces the risk of toxic and side effects on the human body. Compared with the natural extracts, the polypeptide composition has the advantages that the addition quantity of the polypeptide composition in cosmetics or skin external medicine preparations is small, and the effect of promoting skin microcirculation can also be achieved.

Description

technical field [0001] The invention relates to the technical field of functional cosmetics and medicines, in particular to a polypeptide composition for promoting skin microcirculation and its application as a skin microcirculation accelerator. Background technique [0002] Microcirculation is the flow of blood, lymph and interstitial fluid between cells and tissues involved in matter, energy and biological information. It includes both the circulation of blood between arterioles and venules, as well as the circulation of lymph and interstitial fluid. Skin microcirculation is a complex system. The system consists of two parallel vascular plexuses, the deep layer and the superficial layer, which play a role in storing blood, nourishing the skin and maintaining the stability of the skin microcirculation. The change of skin blood flow is affected by many factors such as physiology, pathology and environment. Different states of the skin and topical drugs can cause changes i...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/49A61K31/4172A61K38/08A61P17/00A61Q19/00
CPCA61K8/64A61K8/4946A61Q19/00A61K31/4172A61K38/08A61P17/00A61K2800/592A61K2300/00
Inventor 太美灵敢小双杜志云林丽刘冠廷
Owner INFINITUS (CHINA) CO LTD
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