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Application of recombinant I-type humanized collagen in pelvic floor repair

A collagen and humanized technology, applied in the field of biomedicine, can solve problems such as pain, immune response, chronic erosion, etc., and achieve the effects of promoting early adhesion, promoting expression, and enhancing bladder storage function.

Pending Publication Date: 2021-12-03
SHANXI JINBO BIO PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past clinical attempts to use animal-derived collagen and pelvic floor synthetic mesh to treat FPFD, the effective rate of treatment was above 60%, but there were problems such as local chronic erosion, persistent pain, and immune response, which have been gradually eliminated.

Method used

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  • Application of recombinant I-type humanized collagen in pelvic floor repair
  • Application of recombinant I-type humanized collagen in pelvic floor repair
  • Application of recombinant I-type humanized collagen in pelvic floor repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Research on the therapeutic effect of recombinant type I humanized collagen on rats with pelvic floor dysfunction

[0037] Animal model establishment:

[0038]All animal studies were approved by the Ethics Committee of Chongqing Medical University. Thirty-nine female Sprague-Dawley rats (2 months old) were provided by the Experimental Animal Center of Chongqing Medical University, with an average body weight of 220-260 grams. Rats were fed with food and tap water at a temperature of 22±2°C, humidity of 50-60%, and a light / dark cycle of 12 hours. Rats were divided into sham operation group (Control), model group (FPFD), treatment group (FPFD+hrCOLI), 13 in each group. Modeling method: intraperitoneal injection of urethane (1.2g / kg) to anesthetize rats, remove bilateral ovaries, and then use catheterization to empty the bladder, insert the F12 catheter with the tip removed into the vagina of the rat 2-3cm, and place After injecting 3ml of normal saline, the ...

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Abstract

The invention belongs to the field of biological medicines, relates to application of recombinant I-type humanized collagen in pelvic floor repair, and particularly provides application of the recombinant I-type humanized collagen in preparation of medicines for preventing and / or treating pelvic floor diseases (especially female pelvic floor dysfunction diseases). The recombinant I-type humanized collagen comprises n repetitions of a sequence as shown in SEQ ID No.1, n is an integer greater than or equal to 1, and when n is an integer greater than or equal to 2, the repetitions are directly connected. Experiments prove that the recombinant I-type humanized collagen can enhance the urine storage function of the bladder, improve the abdominal urine leakage point pressure, enhance the tension resistance of the vagina, thicken the intrinsic layer and the muscular layer of the vagina, increase the number of blood vessels and collagenous fibers of connective tissues of the intrinsic layer of the vagina, promote the synthesis of extracellular matrixes and promote the early adhesion of sacral ligament fibroblasts.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the use of recombinant type I humanized collagen in pelvic floor repair. Background technique [0002] Female pelvic floor dysfunction (FPFD) is a group of refractory gynecological diseases caused by damage, degeneration or functional defect of pelvic support structure. With the aging of my country's population, the incidence of FPFD will increase sharply. It is estimated that the incidence of FPFD will exceed 50% in 2050. Currently, pelvic floor reconstruction surgery is the main treatment, but the recurrence rate is 20%-40%. In the past clinical attempts to use animal-derived collagen and pelvic floor synthetic mesh to treat FPFD, the treatment efficiency was above 60%, but there were problems such as local chronic erosion, persistent pain, and immune response, which have gradually been eliminated. The main histopathological features of FPFD include: fibroblast synthesis I / III collage...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P15/00A61P13/00A61P15/02A61P19/04
CPCA61K38/39A61P15/00A61P13/00A61P15/02A61P19/04Y02A50/30
Inventor 杨霞张玢玢刘峥张志强王玲玲胡丽娜李虎董晓静
Owner SHANXI JINBO BIO PHARMA CO LTD
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