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Surface-hydrophobic hydrogel as well as preparation and application thereof

A hydrogel and hydrophobic technology, applied in bandages, coatings, medical science, etc., can solve the problems that the hydrogel cannot be stored for a long time, and achieve the effects of delaying water loss, preventing water loss, and preventing bacterial adhesion

Active Publication Date: 2021-11-26
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The temperature, pH and hyaluronidase sensitivity, in vivo and in vitro injectable and self-healing properties are prepared by using aldylated hyaluronic acid and adipate dihydrazide modified hyaluronic acid and aminoglycoside antibiotics as raw materials. Good mechanical properties and antibacterial properties, these excellent properties can make antibacterial hydrogels applied in the field of tissue engineering and repair, but this technology only solves the antibacterial problem of hydrogels, and does not guarantee that hydrogels can be used for long-term maintenance without losing water. time storage

Method used

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  • Surface-hydrophobic hydrogel as well as preparation and application thereof
  • Surface-hydrophobic hydrogel as well as preparation and application thereof
  • Surface-hydrophobic hydrogel as well as preparation and application thereof

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preparation example Construction

[0039] The preparation of the amphiphilic Janus particles in the present invention can be carried out according to the preparation method of the prior art Janus particles. For example, in one embodiment, the preparation of amphiphilic Janus particles is carried out by dispersing Janus core particles, such as silica, polystyrene, polymethylmethacrylate, polyvinylpyridine or polyethylene oxide particles In the dopamine aqueous solution, the polydopamine coating is obtained by polymerizing on its surface; the polydopamine modified particles are embedded on the surface of paraffin microspheres; then the paraffin balls are soaked in the perfluorodecanethiol solution, and then the paraffin is washed away to obtain Amphiphilic Janus particles with one end hydrophilic and the other hydrophobic.

[0040] The invention also provides the application of the hydrogel for preparing antifouling self-cleaning materials or wound dressing materials.

[0041] The surface hydrophobic hydrogel with...

Embodiment 1

[0047] A method for preparing a hydrophobic surface hydrogel by using amphiphilic Janus particles has the following steps:

[0048] A. Dissolve silicon dioxide in PBS solution (pH=8.5), control the temperature to 25°C in a water bath, add dopamine hydrochloride and stir at constant temperature for 24 hours, wash off unreacted dopamine by centrifugation with deionized water, and freeze-dry the dopamine Add the modified silica to the paraffin wax heated in a 75°C water bath, mix and stir, add the CTAB solution heated in a 75°C water bath to the mixture of silica and paraffin, heat and stir evenly for 30min, filter the silicon dioxide embedded in the silica with gauze paraffin pellets, and the non-paraffin-embedded silica was washed with deionized water and freeze-dried as figure 2 The silica particles shown are partially embedded in paraffin, and the exposed part can be modified by hydrophobic polymers; the paraffin particles embedded in silica are soaked in a mixture of perflu...

Embodiment 2

[0053] A method for preparing surface hydrophobic hydrogel by using amphiphilic Janus particles, comprising the following steps:

[0054] A. Dissolve silicon dioxide in PBS solution (pH=8.5), control the temperature to 25°C in a water bath, add dopamine hydrochloride and stir at constant temperature for 24 hours, wash off unreacted dopamine by centrifugation with deionized water, and freeze-dry the dopamine Add the modified silica to the paraffin wax heated in a 75°C water bath, mix and stir, add the CTAB solution heated in a 75°C water bath to the mixture of silica and paraffin, heat and stir evenly for 30min, filter the silicon dioxide embedded in the silica with gauze Paraffin particles, and the silicon dioxide that is not embedded in paraffin is washed with deionized water, and then freeze-dried to obtain particles in which the silicon dioxide particles are partially embedded in paraffin, and the exposed part can be modified by a hydrophobic polymer; the embedded silica par...

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Abstract

The invention belongs to the field of polymer soft materials, and relates to surface-hydrophobic hydrogel as well as preparation and application thereof. The surface of a hydrogel main body material is modified with amphiphilic Janus particles, the hydrophilic ends of the amphiphilic Janus particles interact with the hydrogel main body, and the hydrophobic ends of the Janus particles form a hydrophobic surface on the surface of the hydrogel main body material, so that the surface-hydrophobic hydrogel is obtained. The hydrophobic surface of the hydrogel can prevent the adsorption of bacteria and pollutants and delay the evaporation of water in the hydrogel, so that the long-term stable storage of the hydrogel is facilitated. The surface-hydrophobic hydrogel has potential application value in the fields of antifouling and self-cleaning, wound dressings and the like.

Description

technical field [0001] The invention belongs to the field of polymer soft matter materials, and more specifically relates to a surface hydrophobic hydrogel, its preparation and application. Background technique [0002] Hydrogel is a cross-linked polymer with a three-dimensional network structure that is hydrophilic and only swells but does not dissolve after absorbing water. Because of its structure similar to biological tissues, hydrogels have properties such as biocompatibility, biodegradability, environmental responsiveness, and low toxicity, making hydrogels widely used in various fields such as medical treatment, sensors, pharmacy, and antifouling. widely used. At present, due to the porous structure of hydrogel, the hydrogel is very easy to lose moisture and become dry and lose its original moist environment. At the same time, because of its biocompatible hydrogel surface, it is easy to be adsorbed by bacteria and pollutants. This brings limitations to the wide appl...

Claims

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Application Information

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IPC IPC(8): C08J7/06C08J3/075C08J3/24C08L33/26C08L79/04C08L79/08C08F220/56C08F222/38A61L26/00
CPCC08J7/06C08J3/075C08J3/246C08F220/56A61L26/008A61L26/0004A61L26/0061A61L26/0014A61L26/0019C08J2333/26C08J2479/04C08J2379/08C08J2433/26C08J2379/04C08L33/26C08L79/04C08L79/08C08F222/385
Inventor 朱锦涛莫敏张连斌高玉洁
Owner HUAZHONG UNIV OF SCI & TECH
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