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Boron quantum dot as well as preparation method and application thereof

A technology of quantum dots and nanosheets, applied in the field of photothermal reagent preparation, can solve problems such as difficulty in large-scale quantitative production, harsh preparation process requirements, and limited clinical treatment applications, and achieve large-scale quantitative production, simple process, environmental protection, etc. friendly effect

Active Publication Date: 2021-11-26
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most quantum dots contain heavy metals and have high cytotoxicity. In addition, the preparation process is demanding, expensive and unstable in the air. It is difficult to achieve large-scale quantitative production, which limits its further application in clinical treatment.

Method used

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  • Boron quantum dot as well as preparation method and application thereof
  • Boron quantum dot as well as preparation method and application thereof
  • Boron quantum dot as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1 A kind of preparation of boron quantum dot

[0031] The method for preparing boron quantum dots by liquid phase stripping comprises the following steps:

[0032] 1. Dissolve 100mg of amorphous boron powder in 100ml of deionized water to obtain a 1mg / ml boron nanosheet dispersion;

[0033] 2. Place the boron nanosheet dispersion obtained in step 1 in an ultrasonic machine with a frequency of 80KHz and a power of 400W, and after ultrasonication in an ice-salt bath at -10°C for 10 hours, a mixed solution is obtained;

[0034] 3. Centrifuge the mixed solution obtained in step 2 for 10 minutes in a centrifuge with a rotating speed of 10,000 rpm / s, take the supernatant and place it in a drying oven to remove water, and the obtained solid is boron quantum dots.

[0035] The boron quantum dots prepared in this embodiment are subjected to X-ray diffraction analysis, and the obtained X-ray diffraction spectrum is as follows figure 1 As shown, will figure 1 Compare...

Embodiment 2

[0039] Embodiment 2 A kind of preparation of boron quantum dot

[0040] The method for preparing boron quantum dots by liquid phase stripping comprises the following steps:

[0041] 1. Dissolve 200mg of amorphous boron powder in 100ml of deionized water to obtain a 2mg / ml boron nanosheet dispersion;

[0042] 2. Place the boron nanosheet dispersion obtained in step 1 in an ultrasonic machine with a frequency of 80KHz and a power of 400W, and after ultrasonication in an ice-salt bath at -10°C for 10 hours, a mixed solution is obtained;

[0043] 3. Centrifuge the mixed solution obtained in step 2 for 10 minutes in a centrifuge with a rotating speed of 10,000 rpm / s, take the supernatant and place it in a drying oven to remove water, and the obtained solid is boron quantum dots.

[0044] Using the method described in Example 1 to detect boron quantum dots, the results show that the boron quantum dots prepared in this example are uniform in size, with a particle size of 1 to 8 nm and...

Embodiment 3

[0045] Embodiment 3 A kind of preparation of boron quantum dot

[0046] The method for preparing boron quantum dots by liquid phase stripping comprises the following steps:

[0047] 1. Dissolve 500mg of amorphous boron powder in 100ml of deionized water to obtain a 5mg / ml boron nanosheet dispersion;

[0048] 2. Place the boron nanosheet dispersion obtained in step 1 in an ultrasonic machine with a frequency of 80KHz and a power of 400W, and after ultrasonication in an ice-salt bath at -10°C for 10 hours, a mixed solution is obtained;

[0049] 3. Centrifuge the mixed solution obtained in step 2 for 10 minutes in a centrifuge with a rotating speed of 10,000 rpm / s, take the supernatant and place it in a drying oven to remove water, and the obtained solid is boron quantum dots.

[0050] The method described in Example 1 is used to detect boron quantum dots, and the boron quantum dots prepared in this example are observed with a transmission electron microscope, and the transmissi...

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Abstract

The invention discloses a boron quantum dot as well as a preparation method and application thereof. The invention provides a preparation method of boron quantum dots. The preparation method comprises the following steps of: dispersing boron powder in water to obtain boron nanosheet dispersion liquid; performing ultrasonic treatment on the boron nanosheet dispersion liquid in an ice salt bath to obtain a mixed solution; centrifuging the mixed solution, taking supernate, and drying to obtain the boron quantum dots. The invention further provides boron quantum dots prepared by the preparation method and application of the boron quantum dots. The boron quantum dots disclosed by the invention have a good photo-thermal treatment effect and also can be used for performing photo-acoustic imaging, so that integration of cancer diagnosis and treatment is realized. Meanwhile, the boron quantum dots can be effectively taken by tumor cells, the toxicity is small, and the cancer treatment effect is good. In addition, the preparation method of the boron quantum dots is simple in process, low in equipment requirement, low in energy consumption and environment-friendly, and can realize large-scale quantitative production.

Description

technical field [0001] The invention relates to the technical field of photothermal reagent preparation. More specifically, it relates to a boron quantum dot and its preparation method and application. Background technique [0002] Cancer is one of the major diseases threatening human health. How to effectively treat cancer has been a research hotspot, but the current traditional treatment methods, such as surgical resection, radiotherapy, and chemotherapy, have problems such as large trauma, easy recurrence, and large side effects. As a new type of cancer treatment, photothermal therapy has attracted widespread attention due to its low toxicity, low invasiveness, and excellent therapeutic effect, and photothermal reagents, which are key materials in photothermal therapy, have always been the focus of research ( CN201910371146.X). At present, in the research of photothermal reagents, a variety of photothermal reagents have been synthesized, and quantum dots with good phot...

Claims

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Application Information

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IPC IPC(8): C01B35/02A61K41/00A61K49/22A61P35/00C09K11/63B82Y20/00B82Y40/00
CPCC01B35/023A61K41/0052A61K49/222A61P35/00C09K11/63B82Y20/00B82Y40/00
Inventor 关山月王莉杨雪婷周树云
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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