Application of water extract of fenxin wood in preparation of medicine for treating ulcerative colitis
A technique for ulcerative colitis, distraction wood, used in the field of medicine
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Embodiment 1
[0037] Example 1: Preparation and component analysis of the water extract of fenugreek
[0038] 1. Preparation of heart wood water extract
[0039] Weigh 1000g of the medicinal material of fenxin, wash it with distilled water, add 10L of distilled water to soak, after soaking for 2h, heat and reflux at 100°C for 1h to extract. The extract was collected, filtered, concentrated to 200mL with a rotary evaporator at 60°C, pre-frozen at -70°C for 6 hours, and vacuum freeze-dried at -50°C for 48 hours to obtain a dark brown water extract of S. 0.82%.
[0040] 2. Composition analysis of the water extract of fenugreek
[0041] The composition of the water extract of the branch wood includes: the total flavonoid content is 33.40±0.88%, the total polysaccharide content is 30.80±2.28%, and the total polyphenol content is 24.62±0.86%.
Embodiment 2
[0042] Example 2: Research on the effect of water extract of fenxinmu on ulcerative colitis in mice
[0043] 1. Animal grouping and dosing regimen
[0044] C57BL / 6 mice, male, 6 weeks old, body weight 20±2g, SPF grade, were purchased from the Animal Center of the Naval Special Medical Center. After the mice were adaptively fed for 5 days, the mice were randomly divided into 4 groups with SPSS software, 10 in each group, respectively, the control group, the model group, the Chinese medicine group (Fanxinmu water extract 500mg / kg), and the positive drug group (Mesalamine 600mg / kg). The model of ulceration was established by DSS induction method: except for the control group, the mice drank 3% DSS solution freely for seven consecutive days. Since the first day of modeling, continuous administration, once a day, for nine consecutive days, the distracted wood group was given 500 mg / kg of the water extract of distracted wood by intragastric administration every day, and the positi...
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