External auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo
A technology for hearing loss and external auditory canal, which is applied in the field of medical devices to achieve the effects of less drug residue, stable performance, and compact and portable finished products
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Embodiment 1
[0032] Embodiment 1: Preparation of L-acetylcysteine nanoliposomes
[0033] L-acetylcysteine nanoliposomes were prepared by ethanol injection-high pressure homogenization method. Accurately weigh 0.1 g of L-acetylcysteine, 0.6 g of soybean lecithin, and 0.03 g of cholesterol, and dissolve them in 4 ml of absolute ethanol. In addition, 0.2 g of sodium cholate was accurately weighed and dissolved in 15 ml of 10 mmol / L phosphate buffer (pH 6.5). Keep warm at 50°C, slowly inject the above-mentioned absolute ethanol solution with a syringe under stirring, and the resulting suspension is processed by a high-pressure homogenizer (1200bar, 3 cycles) to obtain translucent L-acetylcysteine nanolipids Body suspension (total weight 20g).
Embodiment 2
[0034] Embodiment 2: Preparation of L-acetylcysteine nano liposome gel
[0035] 0.8 g of methylcellulose was accurately weighed, and 4.0 g of 1,2-propanediol was added for dispersion. Accurately weigh 0.1 g of allantoin and dissolve it in 15.1 g of phosphate buffer, add it to the above-mentioned 1,2-propanediol, and stir to obtain about 20 g of blank gel matrix.
[0036] Add 20 g of the L-acetylcysteine nanoliposome suspension prepared in Example 1 to the above-mentioned blank gel matrix, and continue stirring until uniform to obtain a total weight of 40 g of L-acetylcysteine nanolipid Plastid gel (L-acetylcysteine content is 2.5mg / g).
Embodiment 3
[0044] Example 3: Preparation of external auditory canal device
[0045] 1. Select the low-pressure foam mold material to make a diameter of 1.2cm, a bullet-shaped earplug 1 with a slightly narrow head of 2.4cm in height (see figure 1 ). Then use the medical silicone 4 to glue the plastic outer protective shell 3 and the earplug 1, so that the two parts are firmly pasted.
[0046] 2. After dipping the earplug 1 into the prepared nanoliposome skeleton gel 2, drain off the excess material to obtain the nanomedicine skeleton gel coating 2. Put the protective shell 5 made of plastic on the outside of the earplug 1 to fully protect the liposome.
[0047] 3. Take two earplugs as a group, put them in the transparent protective box 6, and that’s it.
[0048] Earplug Performance Test
[0049] Using the "artificial ear canal" method, the skeleton gel earplug of the present invention is measured at a given frequency, and its sound insulation varies with the sound level. The skeleton...
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