External auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo

A technology for hearing loss and external auditory canal, which is applied in the field of medical devices to achieve the effects of less drug residue, stable performance, and compact and portable finished products

Pending Publication Date: 2021-11-05
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide an external auditory canal device for the prevention and treatment of noise-induced hearing loss and secondary vertigo. It makes up for the current shortage of purely relying on physical noise reduction for protection.

Method used

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  • External auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo
  • External auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo
  • External auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of L-acetylcysteine ​​nanoliposomes

[0033] L-acetylcysteine ​​nanoliposomes were prepared by ethanol injection-high pressure homogenization method. Accurately weigh 0.1 g of L-acetylcysteine, 0.6 g of soybean lecithin, and 0.03 g of cholesterol, and dissolve them in 4 ml of absolute ethanol. In addition, 0.2 g of sodium cholate was accurately weighed and dissolved in 15 ml of 10 mmol / L phosphate buffer (pH 6.5). Keep warm at 50°C, slowly inject the above-mentioned absolute ethanol solution with a syringe under stirring, and the resulting suspension is processed by a high-pressure homogenizer (1200bar, 3 cycles) to obtain translucent L-acetylcysteine ​​​​nanolipids Body suspension (total weight 20g).

Embodiment 2

[0034] Embodiment 2: Preparation of L-acetylcysteine ​​nano liposome gel

[0035] 0.8 g of methylcellulose was accurately weighed, and 4.0 g of 1,2-propanediol was added for dispersion. Accurately weigh 0.1 g of allantoin and dissolve it in 15.1 g of phosphate buffer, add it to the above-mentioned 1,2-propanediol, and stir to obtain about 20 g of blank gel matrix.

[0036] Add 20 g of the L-acetylcysteine ​​nanoliposome suspension prepared in Example 1 to the above-mentioned blank gel matrix, and continue stirring until uniform to obtain a total weight of 40 g of L-acetylcysteine ​​nanolipid Plastid gel (L-acetylcysteine ​​content is 2.5mg / g).

Embodiment 3

[0044] Example 3: Preparation of external auditory canal device

[0045] 1. Select the low-pressure foam mold material to make a diameter of 1.2cm, a bullet-shaped earplug 1 with a slightly narrow head of 2.4cm in height (see figure 1 ). Then use the medical silicone 4 to glue the plastic outer protective shell 3 and the earplug 1, so that the two parts are firmly pasted.

[0046] 2. After dipping the earplug 1 into the prepared nanoliposome skeleton gel 2, drain off the excess material to obtain the nanomedicine skeleton gel coating 2. Put the protective shell 5 made of plastic on the outside of the earplug 1 to fully protect the liposome.

[0047] 3. Take two earplugs as a group, put them in the transparent protective box 6, and that’s it.

[0048] Earplug Performance Test

[0049] Using the "artificial ear canal" method, the skeleton gel earplug of the present invention is measured at a given frequency, and its sound insulation varies with the sound level. The skeleton...

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PUM

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Abstract

The invention discloses an external auditory canal device for preventing and treating noise-induced hearing impairment and secondary vertigo, the external auditory canal device comprises an earplug and an earplug shell fixedly arranged at the tail end of the earplug, the surface of the earplug is provided with a nano-drug skeleton gel coating, the nano-drug skeleton gel coating is prepared by preparing an antioxidant into nano-liposome, then implanting into a gel matrix to obtain a gel agent, and then coating the gel agent on the surface of the earplug to obtain the earplug. Wherein a framework material for forming the gel matrix is hydroxypropyl methyl cellulose or a medical high polymer material. According to the external auditory canal device, the effect of synchronous prevention and treatment can be achieved when an operator suffers from non-resistant noise injury or at the early stage, and the defect that protection is conducted only through physical noise reduction at present is overcome.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an external auditory canal device for preventing and treating noise-induced hearing loss and secondary vertigo. Background technique [0002] Noise-induced hearing loss, traditionally referred to as acute or chronic acoustic trauma (depending on the duration of exposure), is the most common type of hearing impairment in adults. According to the European Agency for Safety and Health at Work (EU-OSHA, 2011), about 80 million residents in the European Union are exposed to noise exceeding 87dB, which is common in construction, agriculture, industry, and military production and transportation. Noise-induced hearing loss is often followed by a series of discomforts such as dizziness, unsteady balance, tinnitus, and ear fullness, which cause obvious troubles to workers and affect their behavioral capabilities. If the noise level cannot be reduced through technical and organizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F11/08A61M31/00
CPCA61F11/08A61M31/00A61M2210/0662A61M2210/005
Inventor 徐瑾李斐郭玉峰蔡维乐高蕊
Owner SHANGHAI CHANGZHENG HOSPITAL
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